Doesn't It All Come Down to Function? How To Correlate VAR2CSA Antibodies with Protection.
作者信息
Gnidehou Sedami, Yanow Stephanie K
机构信息
Campus Saint-Jean, University of Alberta, Edmonton, Alberta, Canada
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
出版信息
mSphere. 2020 Jun 24;5(3):e00521-20. doi: 10.1128/mSphere.00521-20.
Abstract
摘要
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mSphere of Influence: Going Native, or the Risk of Overreliance on Recombinant Antigens.影响范围：入乡随俗，还是过度依赖重组抗原的风险。
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The Case for Exploiting Cross-Species Epitopes in Malaria Vaccine Design.利用跨物种表位进行疟疾疫苗设计的理由。
Front Immunol. 2020 Feb 27;11:335. doi: 10.3389/fimmu.2020.00335. eCollection 2020.
3
PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study.PRIMVAC 疫苗联合 Alhydrogel 或 GLA-SE 佐剂预防胎盘疟疾：首次人体、随机、双盲、安慰剂对照研究。
Lancet Infect Dis. 2020 May;20(5):585-597. doi: 10.1016/S1473-3099(19)30739-X. Epub 2020 Feb 4.
4
Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between PvDBP and VAR2CSA.抗隐匿表位抗体在 PvDBP 和 VAR2CSA 之间的异源免疫中发挥作用
mBio. 2019 Oct 8;10(5):e02343-19. doi: 10.1128/mBio.02343-19.
5
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J Infect Dis. 2019 Jan 1;219(1):110-120. doi: 10.1093/infdis/jiy467.
6
Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development.恶性疟原虫 var2csa 的全球遗传多样性及其对妊娠疟疾和疫苗开发的影响。
Sci Rep. 2018 Oct 18;8(1):15429. doi: 10.1038/s41598-018-33767-3.
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Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin.贝宁：针对胎盘疟疾的保护性抗体与孕期不良结局
Emerg Infect Dis. 2015 May;21(5):813-23. doi: 10.3201/eid2105.141626.
8
Functional antibodies against VAR2CSA in nonpregnant populations from colombia exposed to Plasmodium falciparum and Plasmodium vivax.哥伦比亚无妊娠人群中针对恶性疟原虫和间日疟原虫的功能性 VAR2CSA 抗体。
Infect Immun. 2014 Jun;82(6):2565-73. doi: 10.1128/IAI.01594-14. Epub 2014 Mar 31.
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Analysis of IgG with specificity for variant surface antigens expressed by placental Plasmodium falciparum isolates.对胎盘恶性疟原虫分离株表达的变异表面抗原具有特异性的IgG分析。
Malar J. 2004 Jul 8;3:21. doi: 10.1186/1475-2875-3-21.
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