Cheng-Mayer C, Levy J A
Department of Medicine, University of California, School of Medicine, San Francisco 94143.
Ann Neurol. 1988;23 Suppl:S58-61. doi: 10.1002/ana.410230716.
Human immunodeficiency viruses from the brain can be distinguished from peripheral blood isolates by their ability to infect established human cell lines and their sensitivity to serum neutralization. Isolates from the brain and lymph nodes obtained from the same person displayed similar host range tropism and susceptibility to serum neutralization; however, the brain isolate infected macrophages more efficiently. These data suggest that brain isolates may represent a distinct subtype of the human immunodeficiency virus.
来自大脑的人类免疫缺陷病毒可通过其感染既定人类细胞系的能力及其对血清中和的敏感性，与外周血分离株区分开来。从同一个人获得的大脑和淋巴结分离株表现出相似的宿主范围嗜性和对血清中和的敏感性；然而，大脑分离株更有效地感染巨噬细胞。这些数据表明，大脑分离株可能代表人类免疫缺陷病毒的一种独特亚型。
