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年龄对腰椎管狭窄症微创腰椎减压手术疗效的影响

The Impact of Age on the Outcomes of Minimally Invasive Lumbar Decompression for Lumbar Spinal Stenosis.

作者信息

Mekhail Nagy A, Costandi Shrif J, Armanyous Sherif, Vallejo Ricardo, Poree Lawrence R, Brown Lora L, Golovac Stanley, Deer Timothy R

机构信息

Evidence-Based Pain Management Research, Cleveland Clinic, Cleveland, OH, USA.

Millennium Pain Center, Bloomington, IL, USA.

出版信息

Med Devices (Auckl). 2020 Jun 4;13:151-161. doi: 10.2147/MDER.S251556. eCollection 2020.

Abstract

BACKGROUND AND PURPOSE

Minimally invasive lumbar decompression ( ) is an effective long-term therapy for patients with symptomatic lumbar spinal stenosis (LSS) resulting primarily from hypertrophic ligamentum flavum (HLF). Most subjects in clinical studies of the procedure have been older adults (age≥65). While the incidence of LSS increases with age, a substantial number of adults (age<65) also suffer from neurogenic claudication secondary to HLF. In this report, outcomes of were compared between adults and older adults.

PATIENTS AND METHODS

All prospective studies of the procedure with a 1-year follow-up completed since the beginning of 2012 that allowed the inclusion of adult patients of all ages were reviewed. Outcomes of visual analog scale (VAS), Oswestry Disability Index (ODI), Pain Disability Index (PDI), Roland Morris Low Back Pain and Disability Questionnaire (RMQ), standing time and walking distance were compared for adults and older adults.

RESULTS

Four studies met the inclusion criteria, resulting in an analysis of 49 adults and 160 older adults. Patients in both age groups experienced significant mean improvements in all but one outcome measure at 6- and 12-month follow-up. Differences between the two age groups in all scores at 6 and 12 months were not statistically significant.

CONCLUSION

Analysis of the four studies indicated that symptom improvements for adults and older adults were significant from baseline, and no statistically significant difference was observed between the two age groups. These results illustrate that can be an effective treatment for LSS due primarily to HLF, regardless of the adult patient age.

摘要

背景与目的

微创腰椎减压术是治疗主要由肥厚性黄韧带(HLF)导致的有症状腰椎管狭窄症(LSS)患者的一种有效的长期治疗方法。该手术临床研究中的大多数受试者为老年人(年龄≥65岁)。虽然LSS的发病率随年龄增长而增加,但相当数量的成年人(年龄<65岁)也患有继发于HLF的神经源性间歇性跛行。在本报告中,比较了成年人与老年人的该手术结果。

患者与方法

回顾了自2012年初以来所有完成1年随访且允许纳入各年龄段成年患者的该手术前瞻性研究。比较了成年人与老年人的视觉模拟量表(VAS)、Oswestry功能障碍指数(ODI)、疼痛障碍指数(PDI)、罗兰·莫里斯下腰痛与功能障碍问卷(RMQ)、站立时间和步行距离的结果。

结果

四项研究符合纳入标准,共分析了49名成年人和160名老年人。在6个月和12个月随访时,两个年龄组的患者除一项结果指标外,其他所有指标的平均改善均显著。两个年龄组在6个月和12个月时所有评分的差异均无统计学意义。

结论

对这四项研究的分析表明,成年人和老年人的症状改善均较基线有显著改善,且两个年龄组之间未观察到统计学上的显著差异。这些结果表明,无论成年患者年龄如何,该手术对于主要由HLF导致的LSS均可作为一种有效的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cedd/7280254/fa5cecab23ba/MDER-13-151-g0001.jpg

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