Zhang Xiaohua, Peng Li, Xie Qing, Wu Qingjing, Sheng Xia
Department of Ophthalmology, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, China.
Front Pharmacol. 2020 Jun 5;11:843. doi: 10.3389/fphar.2020.00843. eCollection 2020.
We report a case of a middle-aged woman who developed hypertensive retinopathy following oral administration of Anlotinib.
A 48-year-old woman presented to our hospital with sudden painless loss of vision in both eyes combined with headache, nausea, and vomiting following oral administration of Anlotinib. This drug is often used to control cancer progression. Due to the deterioration of her blood pressure, which reached 167/113 mm Hg, Anlotinib was discontinued and the blood pressure was controlled by hypertension medications. This normalized her blood pressure, alleviated headache, and restored her vision. She visited our eye department 37 days later for eye check-up. The best-corrected visual acuities was 0.3 in the right eye and 0.4 in the left eye. The fundus examinations revealed a clear boundary of the optic papilla with significant stellate exudation in the macular area. The posterior pole of the retina displayed high hemorrhage, with a cotton-wool spot appearance. Optical coherence tomography (OCT) revealed atrophy in the outer segment of macular area, and hard exudations in retinal layers. Based on these findings, hypertensive retinopathy was diagnosed, as a secondary complication of Anlotinib.
Anlotinib can induce hypertensive retinopathy. Patients receiving this drug should be closely monitored for potential complications.
我们报告一例中年女性在口服安罗替尼后发生高血压性视网膜病变的病例。
一名48岁女性因口服安罗替尼后双眼突然无痛性视力丧失并伴有头痛、恶心和呕吐前来我院就诊。该药物常用于控制癌症进展。由于她的血压恶化至167/113 mmHg，停用了安罗替尼，并通过高血压药物控制血压。这使她的血压恢复正常，头痛缓解，视力恢复。37天后她到我院眼科进行眼部检查。最佳矫正视力右眼为0.3，左眼为0.4。眼底检查显示视乳头边界清晰，黄斑区有明显的星芒状渗出。视网膜后极部有大量出血，呈棉絮斑样外观。光学相干断层扫描（OCT）显示黄斑区外段萎缩，视网膜各层有硬性渗出。基于这些发现，诊断为高血压性视网膜病变，为安罗替尼的继发性并发症。
安罗替尼可诱发高血压性视网膜病变。接受该药物治疗的患者应密切监测潜在并发症。
