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双侧内源性眼内炎误诊为 Purtscher 视网膜病变 1 例

A case of bilateral endogenous endophthalmitis misdiagnosed as Purtscher's retinopathy.

机构信息

Xinqiao Hospital, Army Medical University, 183rd Xinqiao Street, Shapingba District, Chongqing, 400038, China.

出版信息

BMC Ophthalmol. 2020 Apr 6;20(1):131. doi: 10.1186/s12886-020-01399-9.

Abstract

BACKGROUND

Purtscher's retinopathy characterized by the appearance of cotton-wool spots and intraretinal hemorrhage at the posterior pole that commonly occurs after severe head and chest trauma. We report a patient who presented with multiple white retinal patches and retinal hemorrhage forty-two days after a severe thoracoabdominal trauma, which was misdiagnosed as Purtscher's retinopathy.

CASE PRESENTATION

A middle-aged woman presented to the eye clinic complaining of decreased vision and distortion in the right eye forty-two days after thoracoabdominal trauma. Upon first glance at her fundal appearances with multiple white retinal patches and retinal hemorrhage, we considered it to be bilateral Purtscher's retinopathy. No specific treatment was given to her. Ten days later, the four white retinal patches in the right eye joined together with star-shaped hard exudates and radial folds in the macula. This was not consistent with the characteristics of Purtscher's retinopathy. In retrospect, we found that the onset time, shape, and location of the white retinal patches were not cotton-wool spots. A detailed history revealed that she had Staphylococcus aureus septicaemia due to abdominal incision infection, and she underwent intravenous antibiotic therapy. Fundus fluorescein angiography (FFA) revealed hyperpermeable vasculature and extensive fluorescence leakage in the middle and late stages. Optical coherence tomography (OCT) revealed highly reflective exudates in the neuroepithelium and macular edema in the right eye. Taking her history and the FFA and OCT results into consideration, she was diagnosed with bilateral endogenous endophthalmitis.

CONCLUSION

In the present case, multiple white patches and intraretinal hemorrhage at the posterior pole forty-two days after the trauma were not Purtscher's retinopathy. It was bilateral endogenous endophthalmitis. The subretinal abcesses that developed secondary to Staphylococcus aureus infection involved the macula causing decreased vision and distortion in the right eye. We concluded that in the case of multiple white retinal patches at the posterior pole in patients after trauma, especially in patients with infectious disease, Purtscher's retinopathy is not the only possible diagnosis. Correct diagnosis depends on reevaluation of the lesions by FFA and OCT, laboratory investigation and detailed history.

摘要

背景

Purtscher 视网膜病变表现为后极部出现棉絮斑和视网膜内出血,常继发于严重的头胸部创伤。我们报告一例患者,在严重的胸腹部创伤后 42 天出现多发性白色视网膜斑和视网膜出血,最初误诊为 Purtscher 视网膜病变。

病例介绍

一名中年女性因胸腹部创伤后 42 天出现视力下降和右眼视物变形就诊于眼科。第一眼观察到她的眼底有多个白色视网膜斑和视网膜出血,我们考虑为双侧 Purtscher 视网膜病变。未给予她特殊治疗。10 天后,右眼的 4 个白色视网膜斑融合在一起,伴有黄斑区星状硬性渗出物和放射状皱褶。这与 Purtscher 视网膜病变的特征不一致。回顾病史,我们发现白色视网膜斑的发病时间、形态和部位均不符合棉絮斑的特点。详细询问病史发现,患者因腹部切口感染发生金黄色葡萄球菌败血症,给予静脉抗生素治疗。眼底荧光血管造影(FFA)显示中晚期高通透性血管和广泛荧光渗漏。光学相干断层扫描(OCT)显示右眼神经上皮层有高反射性渗出物和黄斑水肿。结合病史和 FFA、OCT 结果,诊断为双侧内源性眼内炎。

结论

本例患者创伤后 42 天出现后极部多发性白色斑和视网膜内出血,并非 Purtscher 视网膜病变,而是双侧内源性眼内炎。金黄色葡萄球菌感染引起的脉络膜下脓肿累及黄斑,导致右眼视力下降和视物变形。我们得出结论,对于创伤后后极部多发性白色视网膜斑的患者,尤其是合并感染性疾病的患者,Purtscher 视网膜病变并非唯一可能的诊断。正确的诊断取决于 FFA 和 OCT 对病变的重新评估、实验室检查和详细的病史。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0070/7137209/84737bcfb70d/12886_2020_1399_Fig1_HTML.jpg

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