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与口服低剂量氯胺酮治疗难治性双相 I 型抑郁症患者相关的情感转换。病例报告及文献综述。

Affective Switch Associated With Oral, Low Dose Ketamine Treatment in a Patient With Treatment Resistant Bipolar I Depression. Case Report and Literature Review.

作者信息

Wilkowska Alina, Szałach Łukasz, Słupski Jakub, Wielewicka Aleksandra, Czarnota Małgorzata, Gałuszko-Węgielnik Maria, Wiglusz Mariusz S, Cubała Wiesław J

机构信息

Department of Psychiatry, Medical University of Gdansk, Gdansk, Poland.

出版信息

Front Psychiatry. 2020 Jun 3;11:516. doi: 10.3389/fpsyt.2020.00516. eCollection 2020.

DOI:10.3389/fpsyt.2020.00516
PMID:32581886
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7283492/
Abstract

There is a growing evidence for the rapid and robust antidepressive effect of ketamine in unipolar and bipolar treatment resistant depression although evidence for the risk of affective switch is still limited. This case presents bipolar I disorder patient with treatment resistant depressive episode experiencing a switch to manic episode with mixed features shortly after receiving eight subanaesthetic doses of oral ketamine as an add-on treatment preceded by 2-day period of manic symptoms.

摘要

越来越多的证据表明，氯胺酮对单相和双相难治性抑郁症具有快速且显著的抗抑郁作用，尽管关于情感转换风险的证据仍然有限。本病例报告了一名双相I型障碍患者，在经历了2天的躁狂症状后，作为附加治疗接受了8次亚麻醉剂量的口服氯胺酮，在接受治疗后不久，难治性抑郁发作转变为具有混合特征的躁狂发作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f81f/7283492/62188352ec0c/fpsyt-11-00516-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f81f/7283492/62188352ec0c/fpsyt-11-00516-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f81f/7283492/62188352ec0c/fpsyt-11-00516-g001.jpg

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Int J Bipolar Disord. 2020 Jan 6;8(1):1. doi: 10.1186/s40345-019-0160-1.
2
Oral Ketamine for Depression, 1: Pharmacologic Considerations and Clinical Evidence.口腔用氯胺酮治疗抑郁症，1：药理学考虑和临床证据。
J Clin Psychiatry. 2019 Apr 2;80(2):19f12820. doi: 10.4088/JCP.19f12820.
3
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Bipolar Disord. 2019 Mar;21(2):176-178. doi: 10.1111/bdi.12728. Epub 2019 Feb 1.
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Psychopharmacology (Berl). 2018 Feb;235(2):393-398. doi: 10.1007/s00213-017-4786-3. Epub 2017 Nov 18.
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