Charpin D, Kleisbauer J P, Lanteaume A, Razzouk H, Vervloet D, Toumi M, Faraj F, Charpin J
Department of Chest Diseases and Allergology, Hôpital Sainte-Marguerite, Marseille, France.
Chest. 1988 Apr;93(4):758-61. doi: 10.1378/chest.93.4.758.
Do subjects living in high altitude where house-dust mites are known to be uncommon exhibit a lower prevalence of asthma and allergy to house-dust mites? To answer this question, we compared the prevalence rates of asthma and skin reactions to house-dust mites in two towns with contrasted environments: Marseille, located on the seashore, and Briançon, 1350 m in altitude. The study population consisted of a random sample of 4,008 people in Marseille and 1,055 people in Briançon. All subjects received a home questionnaire, and a sample of patients and asymptomatic subjects had a skin-prick test evaluation. The cumulative prevalence of asthma was equal to 4.1 percent in Marseille and 2.4 percent in Briançon, a difference which was significant (p = 0.01). The prevalence of positive skin tests to housedust mites in asymptomatic subjects was equal to 27.5 percent in Marseille and 10.2 percent in Briançon (p less than 0.001). This study supports the hypothesis that exposure to environmental factors may have a major influence on developing allergic diseases.
在已知屋尘螨不常见的高海拔地区生活的人群，其哮喘患病率及对屋尘螨过敏的情况是否较低？为回答这个问题，我们比较了两个环境迥异的城镇中哮喘患病率以及对屋尘螨的皮肤反应：位于海滨的马赛和海拔1350米的布里扬松。研究人群包括从马赛随机抽取的4008人以及从布里扬松随机抽取的1055人。所有受试者都收到了一份家庭调查问卷，部分患者和无症状受试者还接受了皮肤点刺试验评估。马赛哮喘的累积患病率为4.1%，布里扬松为2.4%，差异具有统计学意义（p = 0.01）。无症状受试者中对屋尘螨皮肤试验呈阳性的患病率在马赛为27.5%，在布里扬松为10.2%（p < 0.001）。本研究支持以下假设：暴露于环境因素可能对过敏性疾病的发生有重大影响。
