De Re Valli, Caggiari Laura, De Zorzi Mariangela, Fanotto Valentina, Miolo Gianmaria, Puglisi Fabio, Cannizzaro Renato, Canzonieri Vincenzo, Steffan Agostino, Farruggia Piero, Lopci Egesta, d'Amore Emanuele S G, Burnelli Roberta, Mussolin Lara, Mascarin Maurizio
Immunopathology and Cancer Biomarkers, Department of Translational Research, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, PN Italy.
Medical Oncology and Cancer Prevention, Department of Medical Oncology, IRCCS, Centro di Riferimento Oncologico di Aviano (CRO), Aviano, PN Italy.
Infect Agent Cancer. 2020 Jun 23;15:42. doi: 10.1186/s13027-020-00307-6. eCollection 2020.
EBV produces miRNAs with important functions in cancer growth, tumor invasion and host immune surveillance. The discovery of EBV miR-BARTs is recent, and most of their functions are still unknown. Nonetheless, some new studies underline their key roles in EBV-associated malignancies.
In EBV-associated tumors, the expression profile of miR-BARTs varies according to the cell type, autophagic process and signals received from the tumor microenvironment. By the same way of interest is the interaction between tumor cells and the tumor environment by the release of selected EBV miR-BARTs in addition to the tumor proteins trough tumor exosomes.
In this review, we discuss new findings regarding EBV miR-BARTs in Hodgkin lymphoma and gastric cancer. The recent discovery that miRNAs are released by exosomes, including miR-BARTs, highlights the importance of tumor and microenvironment interplay with more specific effects on the host immune response.
EBV产生的微小RNA在癌症生长、肿瘤侵袭和宿主免疫监视中具有重要功能。EBV miR-BARTs的发现时间较近，其大多数功能仍不清楚。尽管如此，一些新研究强调了它们在EBV相关恶性肿瘤中的关键作用。
在EBV相关肿瘤中，miR-BARTs的表达谱因细胞类型、自噬过程以及从肿瘤微环境接收的信号而异。同样有趣的是，除了肿瘤蛋白通过肿瘤外泌体释放外，肿瘤细胞还通过释放特定的EBV miR-BARTs与肿瘤环境相互作用。
在本综述中，我们讨论了关于EBV miR-BARTs在霍奇金淋巴瘤和胃癌中的新发现。最近发现包括miR-BARTs在内的微小RNA可通过外泌体释放，这凸显了肿瘤与微环境相互作用的重要性，对宿主免疫反应具有更具体的影响。
