Fluoxetine and pargyline on the nucleus raphe magnus inhibition of cat multireceptive dorsal horn neurones.
作者信息
Khanna S, Sinclair J G
机构信息
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
出版信息
Gen Pharmacol. 1988;19(2):249-52. doi: 10.1016/0306-3623(88)90070-5.
PMID:3258264
Abstract
- To determine whether serotonin (5-HT) is involved in the nucleus raphe magnus (NRM) inhibition of cat multireceptive dorsal horn neurones, the NRM inhibition was tested with drugs (fluoxetine and pargyline) that should enhance 5-HT synaptic activity. 2. Fluoxetine and pargyline systemically administered, individually or concurrently, decreased rather than increased the inhibition. 3. The results do not support the hypothesis that NRM stimulation-produced inhibition is mediated by 5-HT release.
摘要
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