大环四内酯类抗生素四抗菌素的免疫抑制和抗增殖作用
Immunosuppressive and anti-proliferative effects of a macrotetrolide antibiotic, tetranactin.
作者信息
Tanouchi Y, Shichi H
机构信息
Eye Research Institute of Oakland University, Rochester, Michigan 48063.
出版信息
Immunology. 1988 Mar;63(3):471-5.
Abstract
The macrotetrolide tetranactin suppressed the appearance of experimental autoimmune uveoretinitis induced in Lewis rats with a soluble retinal antigen (S-antigen). The drug at 1 ng/ml inhibited the mitogen activation of unfractionated lymphocytes; incorporation of radiolabelled precursors such as thymidine, uridine and leucine into the cells was markedly reduced. The synthesis and release of IL-2 by mitogen-activated lymphocytes was significantly suppressed in the presence of tetranactin. Incorporation of 45Ca was also inhibited, while intracellular Na+ levels were increased. In view of the ionophore property of tetranactin, it was suggested that the drug might demonstrate its immunosuppressive effect by affecting intracellular cation concentrations.
摘要
大环四内酯类抗生素四活菌素可抑制用可溶性视网膜抗原（S抗原）诱导Lewis大鼠产生的实验性自身免疫性葡萄膜视网膜炎。该药物在浓度为1纳克/毫升时可抑制未分级淋巴细胞的丝裂原激活；放射性标记前体如胸苷、尿苷和亮氨酸掺入细胞的量显著减少。在四活菌素存在的情况下，丝裂原激活的淋巴细胞合成和释放白细胞介素-2受到显著抑制。45Ca的掺入也受到抑制，而细胞内Na+水平升高。鉴于四活菌素的离子载体特性，提示该药物可能通过影响细胞内阳离子浓度发挥免疫抑制作用。
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