Nussenblatt R B, Kuwabara T, de Monasterio F M, Wacker W B
Arch Ophthalmol. 1981 Jun;99(6):1090-2. doi: 10.1001/archopht.1981.03930011090021.
Uveitis was induced rhesus monkeys immunized with purified retinal S-antigen. Focal retinal and subretinal infiltration, in addition to periphlebitic changes, were observed histologically. Immunized monkeys had similar cell-mediated in vitro immune responses to the S-antigen as do humans with posterior uveitis. Circulating immune complexes at the time of disease could not be detected. This primate model supports the notion that the S-antigen may play a role in human uveitis.
用纯化的视网膜S抗原免疫恒河猴诱发葡萄膜炎。组织学观察发现除静脉周炎改变外，还有局灶性视网膜和视网膜下浸润。免疫后的猴子对S抗原的体外细胞介导免疫反应与后葡萄膜炎患者相似。疾病发生时未检测到循环免疫复合物。这个灵长类动物模型支持S抗原可能在人类葡萄膜炎中起作用的观点。
