脑脊液鸢尾素与阿尔茨海默病中的β淀粉样蛋白、脑源性神经营养因子及认知功能相关。
Cerebrospinal fluid irisin correlates with amyloid-β, BDNF, and cognition in Alzheimer's disease.
作者信息
Lourenco Mychael V, Ribeiro Felipe C, Sudo Felipe K, Drummond Cláudia, Assunção Naima, Vanderborght Bart, Tovar-Moll Fernanda, Mattos Paulo, De Felice Fernanda G, Ferreira Sergio T
机构信息
Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro Cidade Universitaria - Rio de Janeiro Rio de Janeiro Brazil.
D'Or Institute for Research and Education (IDOR), Rio de Janeiro Rio de Janeiro Brazil.
出版信息
Alzheimers Dement (Amst). 2020 Jun 21;12(1):e12034. doi: 10.1002/dad2.12034. eCollection 2020.
INTRODUCTION
Irisin is a novel hormone originally identified for its role as a regulator of peripheral metabolism and recently found to protect synapses and rescue memory in mouse models of Alzheimer's disease (AD). However, whether and how cerebrospinal fluid (CSF) irisin varies in relation to canonical AD biomarkers and cognition in humans remains unknown.
METHODS
We determined CSF levels of irisin and brain-derived neurotrophic factor (BDNF) and examined their correlations with CSF amyloid beta (Aβ), total tau, and Mini-Mental State Exam (MMSE) scores in a cohort comprising AD patients ( = 14) and non-demented controls (NDC; = 25).
RESULTS
CSF irisin correlated positively with BDNF, Aβ, and MMSE scores, but not with CSF total tau.
DISCUSSION
Results indicate that CSF irisin and BDNF are directly correlated with Aβ pathology and cognition in AD.
引言
鸢尾素是一种新型激素，最初因其作为外周代谢调节因子的作用而被发现，最近在阿尔茨海默病（AD）小鼠模型中发现它能保护突触并挽救记忆。然而，脑脊液（CSF）鸢尾素在人类中是否以及如何与经典AD生物标志物和认知相关仍不清楚。
方法
我们测定了AD患者（n = 14）和非痴呆对照（NDC；n = 25）队列中脑脊液鸢尾素和脑源性神经营养因子（BDNF）的水平，并检查了它们与脑脊液淀粉样β蛋白（Aβ）、总tau蛋白和简易精神状态检查表（MMSE）评分的相关性。
结果
脑脊液鸢尾素与BDNF、Aβ和MMSE评分呈正相关，但与脑脊液总tau蛋白无关。
讨论
结果表明，脑脊液鸢尾素和BDNF与AD中的Aβ病理和认知直接相关。
Zotero 插件