The School of Biological Sciences, University of Auckland, 3A Symonds St, Auckland 1010, New Zealand.
Org Biomol Chem. 2020 Jul 15;18(27):5073-5094. doi: 10.1039/d0ob00942c.
Agonists of Toll-like Receptor 2 (TLR2) are attractive synthetic targets due to their use as adjuvants in immunotherapies to treat various diseases notably, cancer. An indepth understanding of TLR2 agonist structure-activity relationships is therefore advantageous for the methodical design of vaccines targetting the TLR2 machinery. This review aims to collate and discuss the literature regarding synthetic studies towards TLR2 agonists and the structure-activity relationships thereof. It is hoped that interested readers will gain a holistic understanding of this topic, and will prompt further efforts towards finding effective agonists of TLR2.
TLR2 激动剂（Toll-like Receptor 2 agonists）作为免疫疗法中的佐剂，在治疗各种疾病（尤其是癌症）方面具有吸引力，是一种有吸引力的合成靶标。因此，深入了解 TLR2 激动剂的结构-活性关系有利于有针对性地设计针对 TLR2 机制的疫苗。本篇综述旨在整理和讨论关于 TLR2 激动剂的合成研究及其结构-活性关系的文献。希望感兴趣的读者能全面了解这一课题，并促使人们进一步努力寻找有效的 TLR2 激动剂。
