Neurology and Stroke Unit, ASST Sette Laghi, Circolo Hospital, Viale Borri, 57, 20100, Varese, Italy.
Clinical and Experimental Medicine and Medical Humanities, Center of Research in Medical Pharmacology, University of Insubria, Varese, Italy.
J Neurol. 2020 Nov;267(11):3157-3160. doi: 10.1007/s00415-020-10001-7. Epub 2020 Jun 24.
Recently WHO has declared novel coronavirus disease 2019 (COVID-19) outbreak a pandemic. Acute respiratory syndrome seems to be the most common manifestation of COVID-19. Besides pneumonia, it has been demonstrated that SARS-CoV-2 infection affects multiple organs, including brain tissues, causing different neurological manifestations, especially acute cerebrovascular disease (ischemic and hemorrhagic stroke), impaired consciousness and skeletal muscle injury. To our knowledge, among neurological disorders associated with SARS-CoV2 infection, no Posterior Reversible Encephalopathy Syndrome (PRES) has been described yet. Herein, we report a case of a 64-year old woman with COVID19 infection who developed a PRES, and we suggest that it could be explained by the disruption of the blood brain barrier induced by the cerebrovascular endothelial dysfunction caused by SARS-CoV-2.
最近世界卫生组织宣布 2019 年冠状病毒病（COVID-19）疫情为大流行。急性呼吸综合征似乎是 COVID-19 的最常见表现。除了肺炎，已经证明 SARS-CoV-2 感染会影响多个器官，包括脑组织，引起不同的神经系统表现，特别是急性脑血管病（缺血性和出血性中风）、意识障碍和骨骼肌损伤。据我们所知，在与 SARS-CoV2 感染相关的神经系统疾病中，尚未描述后可逆性脑病综合征（PRES）。在此，我们报告了一例 64 岁女性 COVID19 感染患者发生 PRES 的病例，我们认为这可能是由 SARS-CoV-2 引起的脑血管内皮功能障碍导致血脑屏障破坏引起的。
