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本文引用的文献

1
Hematological findings in coronavirus disease 2019: indications of progression of disease.2019 年冠状病毒病的血液学表现：疾病进展的迹象。
Ann Hematol. 2020 Jul;99(7):1421-1428. doi: 10.1007/s00277-020-04103-5. Epub 2020 Jun 3.
2
Epidemiology and clinical features of COVID-19: A review of current literature.新型冠状病毒肺炎的流行病学和临床特征：文献复习。
J Clin Virol. 2020 Jun;127:104357. doi: 10.1016/j.jcv.2020.104357. Epub 2020 Apr 10.
3
Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past.新型冠状病毒感染患者的凝血功能障碍：COVID-19、SARS-CoV-1、MERS-CoV 及过去的经验教训。
J Clin Virol. 2020 Jun;127:104362. doi: 10.1016/j.jcv.2020.104362. Epub 2020 Apr 9.
4
Severe COVID-19 infection associated with endothelial activation.严重的2019冠状病毒病感染与内皮细胞激活有关。
Thromb Res. 2020 Jun;190:62. doi: 10.1016/j.thromres.2020.04.014. Epub 2020 Apr 15.
5
Mechanism of thrombocytopenia in COVID-19 patients.新型冠状病毒肺炎患者血小板减少的机制。
Ann Hematol. 2020 Jun;99(6):1205-1208. doi: 10.1007/s00277-020-04019-0. Epub 2020 Apr 15.
6
Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2.严重新型冠状病毒肺炎与非新型冠状病毒肺炎患者凝血功能特征的差异。
J Thromb Thrombolysis. 2021 May;51(4):1107-1110. doi: 10.1007/s11239-020-02105-8.
7
Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants.缺氧诱导的补体失调与小鼠气管移植中的微血管损伤有关。
J Transl Med. 2020 Mar 31;18(1):147. doi: 10.1186/s12967-020-02305-z.
8
NADPH oxidase-mediated endothelial injury in HIV- and opioid-induced pulmonary arterial hypertension.NADPH 氧化酶介导致血管内皮损伤在 HIV 和阿片类药物引起的肺动脉高压中的作用。
Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L1097-L1108. doi: 10.1152/ajplung.00480.2019. Epub 2020 Apr 1.
9
Mitochondrial superoxide mediates PM-induced cytotoxicity in human pulmonary lymphatic endothelial cells.线粒体超氧阴离子介导 PM 诱导的人肺淋巴管内皮细胞细胞毒性。
Environ Pollut. 2020 Aug;263(Pt A):114423. doi: 10.1016/j.envpol.2020.114423. Epub 2020 Mar 21.
10
Sirolimus and propranolol inhibit endothelial proliferation while detergent sclerosants induce endothelial activation, microparticle release and apoptosis in vitro.西罗莫司和普萘洛尔抑制内皮细胞增殖，而去污剂硬化剂在体外诱导内皮细胞激活、微颗粒释放和细胞凋亡。
Phlebology. 2020 Sep;35(8):566-575. doi: 10.1177/0268355520913384. Epub 2020 Mar 26.

COVID-19 导致的血管内皮损伤：补体、HIF-1 和 ABL2 是损伤的潜在途径和治疗靶点。

COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure.

机构信息

Hematology Department, Az Osp SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

出版信息

Ann Hematol. 2020 Aug;99(8):1701-1707. doi: 10.1007/s00277-020-04138-8. Epub 2020 Jun 24.

DOI:10.1007/s00277-020-04138-8
PMID:32583086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7312112/
Abstract

COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide. The high reported morbidity has been related to hypoxia and inflammation leading to endothelial dysfunction and aberrant coagulation in small and large vessels. This review addresses some of the pathways leading to endothelial derangement, such as complement, HIF-1α, and ABL tyrosine kinases. This review also highlights potential targets for prevention and therapy of COVID-19-related organ damage and discusses the role of marketed drugs, such as eculizumab and imatinib, as suitable candidates for clinical trials.

摘要

COVID-19 大流行是一场重大的卫生紧急事件，在全球范围内造成数百人死亡。高发病率与缺氧和炎症有关，导致小血管和大血管的内皮功能障碍和异常凝血。这篇综述探讨了导致内皮紊乱的一些途径，如补体、HIF-1α 和 ABL 酪氨酸激酶。这篇综述还强调了预防和治疗 COVID-19 相关器官损伤的潜在靶点，并讨论了上市药物（如依库珠单抗和伊马替尼）作为临床试验合适候选药物的作用。