Department of Child and Adolescent Psychiatry, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey.
Department of Child and Adolescent Psychiatry, Afyonkarahisar Goverment Hospital, Afyon, Turkey.
J Autism Dev Disord. 2021 Feb;51(2):632-643. doi: 10.1007/s10803-020-04579-0.
This study aimed to investigate the role of leptin, ghrelin, neuropeptide Y, and nesfatin-1 in young children with autism spectrum disorder (ASD). A total of 44 children with ASD and 44 healthy controls aged 18-60 months were included. Plasma levels of hormones were measured using commercial enzyme-linked immunosorbent assay kits. Plasma leptin and ghrelin levels were significantly higher in the ASD group than in the control group. However, no significant difference for plasma neuropeptide Y and nesfatin-1 levels was detected between the groups. No relation was found between the severity of ASD symptoms, severity of eating problems, and plasma levels of hormones. Leptin and ghrelin may play a potential role in the pathogenesis of ASD.
本研究旨在探讨瘦素、胃饥饿素、神经肽 Y 和 nesfatin-1 在自闭症谱系障碍（ASD）儿童中的作用。共纳入 44 名 18-60 个月大的 ASD 儿童和 44 名健康对照。使用商业酶联免疫吸附测定试剂盒测量激素的血浆水平。ASD 组的血浆瘦素和胃饥饿素水平明显高于对照组。然而，两组之间的血浆神经肽 Y 和 nesfatin-1 水平没有显著差异。ASD 症状严重程度、进食问题严重程度与激素水平之间无相关性。瘦素和胃饥饿素可能在 ASD 的发病机制中发挥潜在作用。
