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[伊比利亚半岛西北部加利西亚自治区奥伦塞市的多发性硬化症患病率]

[The prevalence of multiple sclerosis in the city of Ourense, Galicia, in the north-west of the Iberian Peninsula].

作者信息

García-Estévez D A, Fraga-González C, Ramos-Pacho M E, López-Díaz L M, Pardo-Parrado M, Prieto J M

机构信息

Complexo Hospitalario de Ourense, Ourense, España.

Centro de Salud Novoa Santos, Ourense, España.

出版信息

Rev Neurol. 2020 Jul 1;71(1):19-25. doi: 10.33588/rn.7101.2019432.

Abstract

INTRODUCTION

Multiple sclerosis is an inflammatory neurodegenerative disease of the central nervous system, which mainly affects young people of working and reproductive age, and represents the first cause of non-traumatic disability in this age group of the population. A north-south latitude gradient is recognised, with prevalence rates increasing as we move away from the equator. This gradient probably represents the genetic predisposition transmitted from the Scandinavian regions through the Viking invasions and could presuppose an influence of the vitamin D deficit related to a lower number of hours of sunshine per year.

AIMS

To determine the prevalence and incidence of multiple sclerosis in the city of Ourense, Galicia.

PATIENTS AND METHODS

The latitude coordinate of the city of Ourense is 42° 34' N. A retrospective epidemiological study covering the period from 2002 to 2016 was conducted. The prevalence date was 31 December 2016. According to the latest census, the population of the city of Ourense was 105,892 on 1 January 2016.

RESULTS

Altogether, 195 cases were recorded, representing a prevalence of 184.1 cases/100,000 inhabitants. In the period 2002-2016, 127 cases of multiple sclerosis were diagnosed, representing an average incidence of 7.86 cases/100,000 inhabitants/year.

CONCLUSION

The city of Ourense has the highest prevalence rate of multiple sclerosis of those studied to date in the Iberian Peninsula, with a figure that brings it closer to the data reported in more northern areas under Nordic and Anglo-American influence.

摘要

引言

多发性硬化症是一种中枢神经系统的炎症性神经退行性疾病,主要影响工作年龄和育龄的年轻人,是该年龄组人群非创伤性残疾的首要原因。人们认识到存在南北纬度梯度,患病率随着远离赤道而增加。这种梯度可能代表了通过维京人入侵从斯堪的纳维亚地区传播的遗传易感性,并且可能意味着与每年日照时间较少相关的维生素D缺乏的影响。

目的

确定加利西亚自治区奥伦塞市多发性硬化症的患病率和发病率。

患者与方法

奥伦塞市的纬度坐标为北纬42°34′。进行了一项涵盖2002年至2016年期间的回顾性流行病学研究。患病率统计日期为2016年12月31日。根据最新的人口普查,2016年1月1日奥伦塞市的人口为105,892人。

结果

共记录了195例病例,患病率为184.1例/10万居民。在2002年至2016年期间,诊断出127例多发性硬化症病例,平均发病率为7.86例/10万居民/年。

结论

奥伦塞市是伊比利亚半岛迄今为止所研究城市中多发性硬化症患病率最高的,这一数字使其更接近受北欧和英美影响的更北部地区报告的数据。

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