Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, TR-34469, Istanbul, Turkey.
Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.
Cell Mol Biol (Noisy-le-grand). 2020 Jun 25;66(4):145-159.
The potential of natural products in cancer prevention and treatment has received worldwide interest in recent years from the nutraceutical and pharmaceutical industry point of view. Medicinal plants have been traditionally used as they exhibit a wide range of therapeutic effects due to their phytoconstituents which play an active role against oxidative stress-associated diseases such as cancer. They may block or suppress multistage carcinogenesis mainly through mechanistic regulation of the myriad of deregulated cellular pathways. Bioactive constituents isolated from different plants have been shown to induce reversal of drug resistance, restoration of apoptosis, inhibition of cell proliferation and stimulation of the immune system, etc. These phytochemicals such as terpenoids, flavonoids, phenolic acids, carotenoids, alkaloids, tannins, anthraquinones, and saponins can be present in any of the plant parts like root, stem, leaves, bark, seed, flower, and fruit which produce a definite physiological response in the organism. Turkish flora is a rich reservoir of wide-ranging bioactive chemicals having premium pharmacological importance. This review provides an overview of the anticancer properties of various Turkish medicinal plant species against different type of cancers via anti-proliferative, genotoxic and cytotoxic effects.
近年来，从营养保健品和制药行业的角度来看，天然产物在癌症预防和治疗方面的潜力引起了全世界的关注。药用植物一直被传统使用，因为它们的植物成分表现出广泛的治疗效果，这些成分在对抗与氧化应激相关的疾病（如癌症）方面发挥着积极的作用。它们可以通过对无数失调细胞途径的机制调节来阻断或抑制多阶段致癌作用。从不同植物中分离出的生物活性成分已被证明可以诱导耐药性逆转、恢复细胞凋亡、抑制细胞增殖和刺激免疫系统等。这些植物化学物质，如萜类化合物、类黄酮、酚酸、类胡萝卜素、生物碱、单宁、蒽醌和皂苷，可能存在于植物的任何部位，如根、茎、叶、树皮、种子、花和果实，它们在生物体中产生明确的生理反应。土耳其植物群是广泛的生物活性化学物质的丰富资源，具有重要的药理学价值。本文综述了各种土耳其药用植物物种通过抗增殖、遗传毒性和细胞毒性作用对不同类型癌症的抗癌特性。
