Ferraccioli G, Savi M
Department of Internal Medicine, University of Parma, Italy.
J Rheumatol. 1988 Jan;15(1):51-3.
Seventy-two patients with rheumatoid arthritis (RA) and 18 with systemic lupus erythematosus (SLE) were typed for HLA class I and II antigens. No association was found with any of the antigens tested. However, B8 and DR3 were increased in patients with extraarticular features (EAF), while DR1 was increased in those with RA without EAF. In SLE a trend towards an increased frequency of DR7 was observed. DR5 was the negative marker in both diseases. Our results confirm the peculiar genetic characteristics in our population.
对72例类风湿性关节炎（RA）患者和18例系统性红斑狼疮（SLE）患者进行了HLA I类和II类抗原分型。未发现与任何检测抗原存在关联。然而，关节外表现（EAF）患者中B8和DR3增加，而无EAF的RA患者中DR1增加。在SLE中，观察到DR7频率增加的趋势。DR5是这两种疾病的阴性标志物。我们的结果证实了我们人群中独特的遗传特征。
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