Bell D A, Rigby R, Stiller C R, Clark W F, Harth M, Ebers G
J Rheumatol. 1984 Aug;11(4):475-9.
Sixty-two Caucasian patients with systemic lupus erythematosus (SLE) were studied to determine whether any significant clinical correlations existed with various HLA antigens. While HLA-B8 and DR3 were significantly increased among the SLE population in general, these or other HLA antigens did not correlate with the severity of renal disease. HLA-B8 was significantly higher only in SLE males compared to male controls. The age of onset of disease in females was clustered into 2 groups, one with early age of onset (mean = 21.6 years, range 12-32 years) and another with later age of onset (mean = 48 years; range 38-60 years). SLE females with later age of onset showed an increased frequency of HLA-DR3 compared to sex and age matched controls, while those with early onset SLE showed no significant increase in any HLA antigens. Therefore any risk conferred by the presence of genes associated with HLA-B8 or DR3 is significant only in SLE males and SLE females whose disease onset was over the age of 35. Despite the greater frequency of HLA-B8, DR3 in SLE females with later onset of disease, this group did not have a greater frequency of anti-Ro antibodies compared to females with early age onset of SLE.
对62名患有系统性红斑狼疮（SLE）的白种人患者进行了研究，以确定各种HLA抗原是否存在任何显著的临床相关性。虽然总体上SLE人群中HLA - B8和DR3显著增加，但这些或其他HLA抗原与肾脏疾病的严重程度无关。与男性对照组相比，仅SLE男性中的HLA - B8显著更高。女性疾病的发病年龄分为两组，一组发病年龄较早（平均 = 21.6岁，范围12 - 32岁），另一组发病年龄较晚（平均 = 48岁；范围38 - 60岁）。与性别和年龄匹配的对照组相比，发病年龄较晚的SLE女性中HLA - DR3的频率增加，而发病早的SLE女性中任何HLA抗原均无显著增加。因此，与HLA - B8或DR3相关基因的存在所带来的任何风险仅在发病年龄超过35岁的SLE男性和SLE女性中显著。尽管发病较晚的SLE女性中HLA - B8、DR3的频率更高，但与发病早的SLE女性相比，该组抗Ro抗体的频率并没有更高。
