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亮光疗法对成年智障人士抑郁症状的影响:一项多中心随机对照试验的结果。

The effect of bright light therapy on depressive symptoms in adults with intellectual disabilities: Results of a multicentre randomized controlled trial.

机构信息

Department of General Practice, Intellectual Disability Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Amarant, Healthcare Organization for People with Intellectual disabilities, Tilburg, The Netherlands.

出版信息

J Appl Res Intellect Disabil. 2020 Nov;33(6):1428-1439. doi: 10.1111/jar.12770. Epub 2020 Jun 25.

Abstract

BACKGROUND

Although a large number of adults with intellectual disabilities have depressive symptoms, non-pharmacological treatments are scarce. The present authors investigated whether bright light therapy (BLT) is effective in decreasing depressive symptoms compared to care as usual.

METHODS

This multicentre randomized controlled trial consisted of three study groups (10,000 lux BLT, dim light BLT and a no-BLT group). Participants received BLT for 30 min in the morning (14 consecutive days), additional to their regular care. Primary outcome was as follows: depressive symptoms measured with the ADAMS Depressive Mood subscale 1 week after the end of BLT (same time period in the no-BLT group).

RESULTS

Forty-one participants were included in our trial. In both BLT groups, a significant decrease in depressive symptoms was seen. No significant differences were found between 10,000 lux BLT and no-BLT (p = .199) and no significant differences between dim light BLT and no-BLT (p = .451). A minimum amount of side effects and no adverse events were reported.

CONCLUSIONS

In both BLT interventions, a decrease in depressive symptoms was seen. With 10,000 lux BLT, depressive symptoms decreased even below the clinical cut-off point, which makes BLT a promising intervention for clinical practice.

摘要

背景

尽管许多成年智障人士都有抑郁症状,但非药物治疗方法却很少。本研究旨在探讨与常规护理相比,强光疗法(BLT)是否能更有效地减轻抑郁症状。

方法

这是一项多中心随机对照试验,包括三个研究组(10000 勒克斯 BLT、低强度 BLT 和无 BLT 组)。参与者在常规护理的基础上,每天早上接受 30 分钟的 BLT(连续 14 天)。主要结局指标为 BLT 结束后 1 周时使用 ADAMS 抑郁情绪量表评估的抑郁症状。

结果

本试验共纳入 41 名参与者。在 BLT 两组中,抑郁症状均显著减轻。10000 勒克斯 BLT 组与无 BLT 组之间无显著差异(p=0.199),低强度 BLT 组与无 BLT 组之间亦无显著差异(p=0.451)。报告的副作用最少,无不良事件。

结论

在 BLT 两种干预措施中,抑郁症状均有所减轻。在 10000 勒克斯 BLT 组中,抑郁症状甚至降低到了临床临界点以下,这使得 BLT 成为一种有前途的临床实践干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf0e/7687277/91cda8852790/JAR-33-1428-g001.jpg

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