Department of General Practice, Intellectual Disability Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Amarant, Healthcare Organization for People with Intellectual Disabilities, Tilburg, The Netherlands.
J Appl Res Intellect Disabil. 2021 Nov;34(6):1549-1559. doi: 10.1111/jar.12899. Epub 2021 May 28.
Depressive symptoms and stress are common in adults with intellectual disabilities. Our aim was to explore long-term biological stress levels, assessed by hair cortisol (HairF) and cortisone (HairE) concentrations, in adults with intellectual disabilities and depressive symptoms and to investigate the effects of bright light therapy (BLT) on hair glucocorticoids.
Scalp hair samples (n = 14) were retrospectively examined at baseline and post-BLT (10.000 and 300 lux). Liquid chromatography-tandem mass spectrometry was used to measure hair glucocorticoids.
A significant correlation was found between baseline HairF and depression scores (r = .605, p = .028). Post-intervention HairE levels were significantly increased ([95% CI: 11.2-17.4 pg/mg], p = .003), in particular after dim light (300 lux) ([95% CI: 10.0-18.3 pg/mg], p = .020).
This study showed that retrospectively examining biological levels of stress in adults with intellectual disabilities seems a potentially promising and objective method to gain insight in the stress level of adults with intellectual disabilities.
抑郁症状和压力在成年智障人士中很常见。我们的目的是探讨通过头发皮质醇（HairF）和皮质酮（HairE）浓度评估的具有抑郁症状的智障成年人的长期生物压力水平，并研究强光治疗（BLT）对头发糖皮质激素的影响。
回顾性地在基线和 BLT 后（10,000 和 300 勒克斯）检查头皮头发样本（n=14）。采用液相色谱-串联质谱法测量头发糖皮质激素。
基线 HairF 与抑郁评分之间存在显著相关性（r=.605，p=.028）。干预后 HairE 水平显著升高（[95%置信区间：11.2-17.4 pg/mg]，p=.003），尤其是在弱光（300 勒克斯）下（[95%置信区间：10.0-18.3 pg/mg]，p=.020）。
这项研究表明，回顾性地检查智障成年人的生物压力水平似乎是一种有前途且客观的方法，可以深入了解智障成年人的压力水平。
