Ceci A, de Terlizzi M, Toma M G, Calculli G, Caputo R, Castello M, Indolfi P, Rosati D
2nd Pediatric Department, University of Bari, Italy.
Med Pediatr Oncol. 1988;16(2):111-5. doi: 10.1002/mpo.2950160209.
Response to treatment with daily intramuscularly administered crude calf thymic extract (Suppressin) in 11 patients with Langerhan's histiocytosis (L.H.) is reported. In ten patients, T-lymphocytic subsets were studied before starting immunotherapy: OKT3 positive and OKT4 positive cells were reduced in four patients; OKT8 positive cells were reduced in two patients; three patients were normal. After immunotherapy, one patient entered complete remission, four patients had stationary disease, and six had marked clinical progression. Subsequently eight patients underwent conventional chemotherapy, and only three entered complete remission. This study has demonstrated the heterogeneity of immunological patterns in L.H. and justifies the necessity for investigations on the immunoregulatory mechanism of L.H.
报告了11例朗格汉斯组织细胞增多症（L.H.）患者每日肌肉注射粗制小牛胸腺提取物（抑制素）的治疗反应。在10例患者中，在开始免疫治疗前研究了T淋巴细胞亚群：4例患者OKT3阳性和OKT4阳性细胞减少；2例患者OKT8阳性细胞减少；3例患者正常。免疫治疗后，1例患者完全缓解，4例患者病情稳定，6例有明显临床进展。随后8例患者接受了传统化疗，只有3例完全缓解。本研究证明了L.H.免疫模式的异质性，并证明了对L.H.免疫调节机制进行研究的必要性。
