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本文引用的文献

1
Increasing venoarterial extracorporeal membrane oxygenation flow puts higher demands on left ventricular work in a porcine model of chronic heart failure.在慢性心力衰竭猪模型中，增加静脉-动脉体外膜肺氧合流量对左心室做功提出了更高要求。
J Transl Med. 2020 Feb 13;18(1):75. doi: 10.1186/s12967-020-02250-x.
2
Intravenous administration of normal saline may be misinterpreted as a change of end-expiratory lung volume when using electrical impedance tomography.使用电阻抗断层成像技术时，静脉输注生理盐水可能会被误判为潮气末肺容积的变化。
Sci Rep. 2019 Apr 8;9(1):5775. doi: 10.1038/s41598-019-42241-7.
3
Changes in Electrical Impedance Tomography Findings of ICU Patients during Rapid Infusion of a Fluid Bolus: A Prospective Observational Study.快速输注液体负荷期间ICU患者电阻抗断层扫描结果的变化：一项前瞻性观察研究。
Am J Respir Crit Care Med. 2019 Jun 15;199(12):1572-1575. doi: 10.1164/rccm.201812-2252LE.
4
Permissive fluid volume in adult patients undergoing extracorporeal membrane oxygenation treatment.成人患者行体外膜肺氧合治疗时的允许性液体容量。
Crit Care. 2018 Oct 27;22(1):270. doi: 10.1186/s13054-018-2211-x.
5
Electrical impedance tomography in acute respiratory distress syndrome.急性呼吸窘迫综合征的电阻抗断层成像。
Crit Care. 2018 Oct 25;22(1):263. doi: 10.1186/s13054-018-2195-6.
6
Left ventricular unloading during veno-arterial ECMO: a review of percutaneous and surgical unloading interventions.静脉-动脉体外膜肺氧合期间的左心室卸载：经皮和外科卸载干预的综述
Perfusion. 2019 Mar;34(2):98-105. doi: 10.1177/0267659118794112. Epub 2018 Aug 16.
7
Severe acute heart failure - experimental model with very low mortality.严重急性心力衰竭——死亡率极低的实验模型。
Physiol Res. 2018 Aug 16;67(4):555-562. doi: 10.33549/physiolres.933774. Epub 2018 May 10.
8
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine.心动过速诱发的心肌病作为猪的慢性心力衰竭模型
J Vis Exp. 2018 Feb 17(132):57030. doi: 10.3791/57030.
9
Detection of microembolic signals in the common carotid artery using Doppler sonography in the porcine model of acute heart failure treated by veno-arterial extracorporeal membrane oxygenation.在静脉-动脉体外膜肺氧合治疗急性心力衰竭的猪模型中，使用多普勒超声检测颈总动脉中的微栓塞信号。
Physiol Res. 2017 Dec 30;66(Suppl 4):S529-S536. doi: 10.33549/physiolres.933806.
10
Electrical impedance tomography: Amplitudes of cardiac related impedance changes in the lung are highly position dependent.电阻抗断层成像：肺部与心脏相关的阻抗变化幅度高度依赖于位置。
PLoS One. 2017 Nov 16;12(11):e0188313. doi: 10.1371/journal.pone.0188313. eCollection 2017.

增加静脉-动脉体外膜肺氧合流量可降低猪急性心力衰竭肺区的电阻抗。

Increasing Veno-Arterial Extracorporeal Membrane Oxygenation Flow Reduces Electrical Impedance of the Lung Regions in Porcine Acute Heart Failure.

机构信息

Department of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.

出版信息

Physiol Res. 2020 Aug 31;69(4):609-620. doi: 10.33549/physiolres.934429. Epub 2020 Jun 25.

DOI:10.33549/physiolres.934429
PMID:32584136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8549886/
Abstract

Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is a technique used in patients with severe heart failure. The aim of this study was to evaluate its effects on left ventricular afterload and fluid accumulation in lungs with electrical impedance tomography (EIT). In eight swine, incremental increases of extracorporeal blood flow (EBF) were applied before and after the induction of ischemic heart failure. Hemodynamic parameters were continuously recorded and computational analysis of EIT was used to determine lung fluid accumulation. With an increase in EBF from 1 to 4 l/min in acute heart failure the associated increase of arterial pressure (raised by 44%) was accompanied with significant decrease of electrical impedance of lung regions. Increasing EBF in healthy circulation did not cause lung impedance changes. Our findings indicate that in severe heart failure EIT may reflect fluid accumulation in lungs due to increasing EBF.

摘要

静脉-动脉体外膜肺氧合（VA ECMO）是一种用于严重心力衰竭患者的技术。本研究旨在评估其对电阻抗断层成像（EIT）中左心室后负荷和肺部液体积累的影响。在 8 头猪中，在诱导缺血性心力衰竭之前和之后应用递增的体外血流（EBF）。连续记录血流动力学参数，并使用 EIT 的计算分析来确定肺液积累。在急性心力衰竭中，EBF 从 1 增加到 4 l/min 时，动脉压的升高（升高 44%）伴随着肺区域电阻抗的显著降低。在健康循环中增加 EBF 不会引起肺阻抗的变化。我们的研究结果表明，在严重心力衰竭中，EIT 可能反映由于 EBF 增加导致的肺部液体积累。