增加静脉-动脉体外膜肺氧合流量可降低猪急性心力衰竭肺区的电阻抗。
Increasing Veno-Arterial Extracorporeal Membrane Oxygenation Flow Reduces Electrical Impedance of the Lung Regions in Porcine Acute Heart Failure.
机构信息
Department of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
出版信息
Physiol Res. 2020 Aug 31;69(4):609-620. doi: 10.33549/physiolres.934429. Epub 2020 Jun 25.
Abstract
Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is a technique used in patients with severe heart failure. The aim of this study was to evaluate its effects on left ventricular afterload and fluid accumulation in lungs with electrical impedance tomography (EIT). In eight swine, incremental increases of extracorporeal blood flow (EBF) were applied before and after the induction of ischemic heart failure. Hemodynamic parameters were continuously recorded and computational analysis of EIT was used to determine lung fluid accumulation. With an increase in EBF from 1 to 4 l/min in acute heart failure the associated increase of arterial pressure (raised by 44%) was accompanied with significant decrease of electrical impedance of lung regions. Increasing EBF in healthy circulation did not cause lung impedance changes. Our findings indicate that in severe heart failure EIT may reflect fluid accumulation in lungs due to increasing EBF.
摘要
静脉-动脉体外膜肺氧合（VA ECMO）是一种用于严重心力衰竭患者的技术。本研究旨在评估其对电阻抗断层成像（EIT）中左心室后负荷和肺部液体积累的影响。在 8 头猪中，在诱导缺血性心力衰竭之前和之后应用递增的体外血流（EBF）。连续记录血流动力学参数，并使用 EIT 的计算分析来确定肺液积累。在急性心力衰竭中，EBF 从 1 增加到 4 l/min 时，动脉压的升高（升高 44%）伴随着肺区域电阻抗的显著降低。在健康循环中增加 EBF 不会引起肺阻抗的变化。我们的研究结果表明，在严重心力衰竭中，EIT 可能反映由于 EBF 增加导致的肺部液体积累。
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