ZBP1：STARGATE 解码 Z 核酸在疾病中的生物学功能
ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease.
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN.
出版信息
J Exp Med. 2020 Jul 6;217(7). doi: 10.1084/jem.20200885.
Abstract
ZBP1 triggers NLRP3 inflammasome activation/pyroptosis, apoptosis, and necroptosis; the specific ligand for ZBP1 activation remains ambiguous. Recent studies, including Devos et al. in this issue of JEM (https://doi.org/10.1084/jem.20191913), collectively suggest that ZBP1 sensing Z-nucleic acids is critical for cell death/inflammatory disease.
摘要
ZBP1 触发 NLRP3 炎性体激活/细胞焦亡、细胞凋亡和坏死；ZBP1 激活的特定配体仍不明确。最近的研究，包括 Devos 等人在本期《实验医学杂志》（https://doi.org/10.1084/jem.20191913）中的研究，共同表明 ZBP1 对 Z 核酸的感应对于细胞死亡/炎症性疾病至关重要。
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