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[慢性间歇性肌电刺激对高脂血症和动脉循环障碍患者影响的初步经验]

[Initial experiences with the effect of chronic intermittent electromyostimulation in patients with hyperlipoproteinemias and arterial circulatory disorders].

作者信息

Kuklinski B, Gibas P, Köhler H, Grossmann K D, Rühlmann C, Zimmermann R, Voigt H, Reuter W, Duck H J, Bühnert G

机构信息

Klinik für Innere Medizin, Karl-Marx-Universität, Leipzig.

出版信息

Z Gesamte Inn Med. 1988 Jan 1;43(1):6-11.

PMID:3258458
Abstract

Metabolic and clinical effects of an original electromyostimulation are explained which induces muscle contractions by changes of the field intensity in the region of microseconds in forms of delivered impulse groups. On account of the good local compatibility due to optimal irritation parameters the muscle stimulator was suitable for a long-term application. Examinations on 23 patients with hyperlipoproteinaemia and mixed HLP (n = 15) and primary hypercholesterolaemia (n = 8) after a 2 times 2 hours/day mutual stimulation of the femoral musculature in a frequency of 2 s-1 lasting four weeks yielded a significant decrease of the triglyceride and cholesterol concentrations as well as an increase of the HDL-cholesterol in mixed HLP-forms. Examinations not yet finished refer to an increase of the extrahepatic activity of the postheparin-lipoprotein lipase and to the concentration of the HDL2-cholesterol. An influence of the hypercholesterolaemia IIa could not be made evident. An electrostimulation performed for 3 months in 8 patients with obliterating arteriosclerosis resulted in a more sufficient collateral blood supply of the legs. The long-term use of the device was unobjectionable also under ambulatory conditions. On the basis of additionally gathered experiences further indications of an electrostimulation were cited. Possible variations of the electrostimulation irritation parameters might make accessible further fields for the preventive and curative medicine.

摘要

阐述了一种原始肌电刺激的代谢和临床效果,该刺激通过以脉冲组形式在微秒级区域改变场强来诱发肌肉收缩。由于最佳刺激参数具有良好的局部兼容性,该肌肉刺激器适合长期应用。对23例高脂蛋白血症患者进行检查,其中混合性高脂蛋白血症(n = 15)和原发性高胆固醇血症(n = 8)患者,每天两次、每次2小时以2次/秒的频率相互刺激股部肌肉,持续四周,结果显示混合性高脂蛋白血症患者的甘油三酯和胆固醇浓度显著降低,高密度脂蛋白胆固醇增加。尚未完成的检查表明肝素后脂蛋白脂肪酶的肝外活性增加以及高密度脂蛋白2胆固醇浓度增加。高胆固醇血症IIa型的影响尚不明显。对8例闭塞性动脉硬化患者进行3个月的电刺激,结果显示腿部侧支血液供应更加充足。在动态条件下长期使用该设备也无问题。基于额外积累的经验,列举了电刺激的更多适应症。电刺激刺激参数的可能变化可能为预防和治疗医学开辟更多领域。

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