Cipparrone L, Ginanneschi A, Degl'Innocenti F, Porzio P, Pagnini P, Marini P
Department of Audiology, University of Florence, Italy.
Acta Neurol Scand. 1988 Jan;77(1):6-11. doi: 10.1111/j.1600-0404.1988.tb06966.x.
The authors studied a group of 36 patients with idiopathic Parkinson's disease by electro-oculographic examination in order to evaluate the most frequent vestibular and oculomotor findings. Vestibular alterations were detected mainly in caloric nystagmus (82.9%). Hyperreflectivity was the most frequent evidence, but it does not necessarily represent the sign of a lesion. The occurrence of spontaneous and evoked nystagmus was not significant. Oculomotor findings were more interesting, as they were altered in two-thirds of the cases. Particularly, saccadic eye movements presented a "multiple step" morphology in 58.3% of the series. This saccadic disarrangement was scarcely found in neurological patients with brainstem and/or cerebellum pathology (7.7%). Moreover, in Parkinson's disease patients no other saccadic alterations typical of brainstem or cerebellum involvement were found. Such observations suggest a possible non-cerebellar origin of "multiple step". Vestibular and oculomotor findings were not significantly correlated with the clinical features of the patients.
作者通过眼电图检查对一组36例特发性帕金森病患者进行了研究，以评估最常见的前庭和动眼神经检查结果。前庭改变主要在冷热试验性眼震中被检测到（82.9%）。高反射性是最常见的表现，但它不一定代表病变的体征。自发性和诱发性眼震的发生率无统计学意义。动眼神经检查结果更有趣，因为在三分之二的病例中出现了改变。特别是，在该系列的58.3%中，眼球扫视运动呈现出“多步”形态。这种扫视紊乱在患有脑干和/或小脑病变的神经疾病患者中很少见（7.7%）。此外，在帕金森病患者中未发现其他典型的脑干或小脑受累的扫视改变。这些观察结果提示“多步”可能起源于非小脑部位。前庭和动眼神经检查结果与患者的临床特征无显著相关性。
