Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, United Kingdom.
Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, United Kingdom.
Pharmacol Ther. 2020 Oct;214:107610. doi: 10.1016/j.pharmthera.2020.107610. Epub 2020 Jun 23.
The Inhibitor of Apoptosis proteins (IAPs) are a family of proteins that are mainly known for their anti-apoptotic activity and ability to directly bind and inhibit caspases. Recent research has however revealed that they have extensive roles in governing numerous other cellular processes. IAPs are known to modulate ubiquitin (Ub)-dependent signaling pathways through their E3 ligase activity and influence activation of nuclear factor κB (NF-κB). In this review, we discuss the involvement of IAPs in individual hallmarks of cancer and the current status of therapies targeting these critical proteins.
凋亡抑制蛋白（IAPs）是一组蛋白，主要因其抗凋亡活性和直接结合并抑制半胱氨酸天冬氨酸蛋白酶（caspases）的能力而闻名。然而，最近的研究表明，它们在调节许多其他细胞过程中具有广泛的作用。IAPs 通过其 E3 连接酶活性调节泛素（Ub）依赖性信号通路，并影响核因子 κB（NF-κB）的激活。在这篇综述中，我们讨论了 IAPs 在癌症各个标志中的作用以及针对这些关键蛋白的治疗方法的现状。
