补体在新生儿ABO溶血病中未被激活。

Complement is not activated in ABO-haemolytic disease of the newborn.

作者信息

Brouwers H A, Overbeeke M A, Huiskes E, Bos M J, Ouwehand W H, Engelfriet C P

机构信息

Central Laboratory the Netherlands Red Cross Blood Transfusion Service, Amsterdam.

出版信息

Br J Haematol. 1988 Mar;68(3):363-6. doi: 10.1111/j.1365-2141.1988.tb04215.x.

DOI:10.1111/j.1365-2141.1988.tb04215.x

PMID:3258530

Abstract

We studied the lysis in vitro of group A red cells by IgG anti-A. IgG anti-A, which strongly lysed A red cells from adults, did not lyse A red cells from cord blood, if fresh cord serum from a child with blood group AB was used as a source of complement. In cases of haemolytic disease of the newborn due to A-O or B-O antagonism with a positive direct antiglobulin test with anti-IgG serum, the red cells did not react with anti-complement sera. Apparently, complement is also not activated in vivo in case of A-O haemolytic disease of the newborn.

摘要

我们研究了IgG抗A对A组红细胞的体外溶解作用。IgG抗A能强烈溶解成人的A组红细胞，但如果使用AB血型儿童的新鲜脐血血清作为补体来源，则不能溶解脐血中的A组红细胞。在因A-O或B-O血型不合导致的新生儿溶血病且抗IgG血清直接抗球蛋白试验呈阳性的病例中，红细胞不与抗补体血清发生反应。显然，在新生儿A-O溶血病的情况下，体内补体也未被激活。