Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Urology Unit, ASST Spedali Civili of Brescia. Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, Italy.
Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Department of Urology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Turin, Italy.
Cancer Epidemiol. 2020 Aug;67:101762. doi: 10.1016/j.canep.2020.101762. Epub 2020 Jun 22.
The burden of renal cell carcinoma (RCC) in young adults received marginal attention. We assessed contemporary gender, race and stage-specific incidence and trends of RCC among young adults (20-39 years-old) in the United States.
Within Surveillance, Epidemiology, and End Results database (2000-2016), patients aged 20-39 years with histologically confirmed RCC were included. Age-standardized incidence rates (ASR per 100,000 person-years) were estimated. Temporal trends were calculated through joinpoint regression analyses to describe the average annual percent change (AAPC).
From 2000-2016, 7767 new RCC cases were recorded (ASR 0.6, AAPC + 5.0 %, p < 0.001). ASRs were higher in males than in females (0.7 and 0.5, respectively) and increased significantly in both genders (AAPC + 5.0 % and +4.7 % both p < 0.001, respectively). Non-Hispanic American Indian/Alaska Native had the highest incidence (ASR 1.0) vs. non-Hispanic Asian or Pacific Islander the lowest (ASR 0.3). ASRs significantly increased in all ethnic groups. T1aN0M0 and T1bN0M0 stages showed the highest incidence and increase (ASR 0.3, AAPC + 5.9 %, p < 0.001 and ASR 0.1, AAPC + 5.7 %, p < 0.001, respectively). Also regional and distant stages increased (AAPC + 3.7 %, p = 0.001 and AAPC + 1.5 %, p = 0.06). The most frequent tumor characteristics were G2 (44.4 %, ASR 0.3, AAPC + 6.3 %, p < 0.001) and G1 (13.1 %, ASR 0.1, AAPC + 1.1 %, p = 0.2), as well as clear cell histology (54.8 %, ASR 0.3, AAPC + 7.6 %, p < 0.001).
RCC in young adults is rare, but increasing. This is mainly due to T1aN0M0 tumors. Nonetheless, also regional diseases are significantly increasing. Differences between ethnic groups exist and may warrant further research.
在年轻人中，肾细胞癌（RCC）的负担受到了忽视。我们评估了美国年轻人（20-39 岁）中 RCC 的当代性别、种族和特定阶段的发病率和趋势。
在监测、流行病学和结果数据库（2000-2016 年）中，纳入了经组织学证实患有 RCC 的 20-39 岁患者。估计了年龄标准化发病率（每 100,000 人年的发病率）。通过连接点回归分析计算时间趋势，以描述平均年度百分比变化（AAPC）。
2000-2016 年期间，记录了 7767 例新的 RCC 病例（发病率为 0.6，AAPC+5.0%，p<0.001）。男性的发病率高于女性（分别为 0.7 和 0.5），且在两性中均显著增加（AAPC+5.0%和+4.7%，均 p<0.001）。非西班牙裔美洲印第安人/阿拉斯加原住民的发病率最高（发病率为 1.0），而非西班牙裔亚洲人或太平洋岛民的发病率最低（发病率为 0.3）。所有种族群体的发病率均显著增加。T1aN0M0 和 T1bN0M0 期的发病率和增长率最高（发病率为 0.3，AAPC+5.9%，p<0.001和发病率为 0.1，AAPC+5.7%，p<0.001）。局部和远处阶段的发病率也有所增加（AAPC+3.7%，p=0.001 和 AAPC+1.5%，p=0.06）。最常见的肿瘤特征是 G2（44.4%，发病率为 0.3，AAPC+6.3%，p<0.001）和 G1（13.1%，发病率为 0.1，AAPC+1.1%，p=0.2）以及透明细胞组织学（54.8%，发病率为 0.3，AAPC+7.6%，p<0.001）。
年轻人中的 RCC 很少见，但在增加。这主要是由于 T1aN0M0 肿瘤。尽管如此，局部疾病也在显著增加。不同种族之间存在差异，可能需要进一步研究。
