Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
Trends Endocrinol Metab. 2020 Sep;31(9):670-679. doi: 10.1016/j.tem.2020.05.007. Epub 2020 Jun 22.
The human insulin-like growth factor 2 (IGF2) mRNA binding protein family (IMPs/IGF2BPs) is involved in a spectrum of biological processes, including development, tumorigenesis, and stemness. IMPs play a major role in post-transcriptional regulation of RNAs through the ribonucleoprotein complex (RNP). They have emerged as direct mammalian target of rapamycin (mTOR) substrates that coordinate nutrient stimulation and RNA life cycle control. IMP2 is a human type 2 diabetes (T2D) gene associated with impaired insulin secretion. Recently, using murine models, the substantial progress in understanding disease mechanisms has highlighted the significance of IMP2 in metabolism. This new knowledge may have the potential for therapeutic benefit.
人类胰岛素样生长因子 2（IGF2）mRNA 结合蛋白家族（IMPs/IGF2BPs）参与了一系列生物学过程，包括发育、肿瘤发生和干性。IMPs 通过核糖核蛋白复合物（RNP）在 RNA 的转录后调控中发挥主要作用。它们已成为直接的哺乳动物雷帕霉素靶蛋白（mTOR）底物，协调营养刺激和 RNA 生命周期控制。IMP2 是与胰岛素分泌受损相关的人类 2 型糖尿病（T2D）基因。最近，使用鼠模型，在理解疾病机制方面取得了重大进展，突出了 IMP2 在代谢中的重要性。这些新知识有可能带来治疗益处。
