丹麦德国牧羊犬甲型血友病的一项研究。

A study of hemophilia A in German shepherd dogs in Denmark.

作者信息

Fogh J M

机构信息

Department of In Vitro Biology, Nordisk Gentofte A/S, Denmark.

出版信息

Vet Clin North Am Small Anim Pract. 1988 Jan;18(1):245-54. doi: 10.1016/s0195-5616(88)50019-0.

DOI:10.1016/s0195-5616(88)50019-0

PMID:3258687

Abstract

Classical hemophilia, hemophilia A, is the most common coagulation disorder in dogs. This article presents a comprehensive study of this disease in German Shepherd dogs in Denmark. Emphasis is placed on pathophysiology, diagnosis, genetics, therapy, and prophylaxis. Furthermore, a scheme for a rational elimination of the causative gene from the population is presented.

摘要

典型血友病，即血友病A，是犬类中最常见的凝血障碍疾病。本文对丹麦德国牧羊犬的这种疾病进行了全面研究。重点在于病理生理学、诊断、遗传学、治疗和预防。此外，还提出了一种从种群中合理消除致病基因的方案。