Fogh J M, Nygaard L, Andresen E, Nilsson I M
Nord Vet Med. 1984 Jul-Aug;36(7-8):241-52.
Clinical data, pedigrees, screening tests (APTT, PT and TT) and specific tests (VIII:C, VIIIC:Ag, VIIIR:Ag and IX:C) were used to diagnose hemophilia A (classical hemophilia) in two colonies of German Shepherd dogs in Denmark. The affected individuals in both colonies were males, and they descended from a common, hemophilic ancestor. All observations were in accordance with X-linked, recessive inheritance. Therapeutic and prophylactic measures are discussed.
临床数据、家系、筛查试验（活化部分凝血活酶时间、凝血酶原时间和凝血酶时间）以及特异性试验（因子VIII：C、因子VIII C：抗原、血管性血友病因子抗原和因子IX：C）被用于诊断丹麦两个德国牧羊犬群体中的甲型血友病（经典血友病）。两个群体中受影响的个体均为雄性，它们源自一个共同的血友病祖先。所有观察结果均符合X连锁隐性遗传。文中讨论了治疗和预防措施。
