Early trends and predictors of renal function following computed tomography-guided percutaneous cryoablation of a renal mass in patients with and without prior renal impairment.

OBJECTIVE

To assess trends and predictors of the glomerular filtration rate (GFR) after renal mass cryoablation in patients with and without history of renal impairment.

MATERIALS AND METHODS

This was a retrospective study of 39 patients who underwent computed tomography-guided percutaneous cryoablation of a renal mass, divided into two groups: those with prior renal impairment (PRI+); and those without prior renal impairment (PRI-). The GFR trend and the chronic kidney disease stage were evaluated at baseline, as well as at 1, 6, and 12 months after cryoablation. Predictors of GFR at 1 and 6 months were modeled with linear regression.

RESULTS

In both groups, the mean GFR at 1 month and 6 months was significantly lower than at baseline ( < 0.001 and = 0.01, respectively). Although the GFR was lower across all time points in the PRI+ group (-26.1; < 0.001), the overall trend was not statistically different from that observed in the PRI- group ( = 0.89). Univariate analysis showed that the decline in GFR at 1 and 6 months correlated with the baseline GFR (0.77 and 0.63; < 0.001 and = 0.03, respectively) and with the size of the ablation zone (-7.6 and -12.84, respectively; = 0.03 for both). However, in the multivariate model, baseline GFR was predictive only of GFR at 1 month ( < 0.001).

CONCLUSION

The trend in GFR decline after cryoablation is similar for patients with and without a history of renal impairment. Baseline GFR predicts the mean GFR in the early post-cryoablation period.