Ceccherini Elisa, Cecchettini Antonella, Morales Maria Aurora, Rocchiccioli Silvia
Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Front Pharmacol. 2020 Jun 10;11:813. doi: 10.3389/fphar.2020.00813. eCollection 2020.
Primary sclerosing cholangitis is a complex pathological condition, characterized by chronic inflammation and fibrosis of the biliary epithelium. Without proper clinical management, progressive bile ducts and liver damage lead to cirrhosis and, ultimately, to liver failure. The known limited role of current drugs for treating this cholangiopathy has driven researchers to assess alternative therapeutic options. Some herbal remedies and their phytochemicals have shown anti-fibrotic properties in different experimental models of hepatic diseases and, occasionally, in clinical trials in primary sclerosing cholangitis patients; however their mechanism of action is not completely understood. This review briefly examines relevant studies focusing on the potential anti-fibrotic properties of , , , and quercetin. Each natural product is individually reviewed and the possible mechanisms of action discussed.
原发性硬化性胆管炎是一种复杂的病理状况，其特征为胆管上皮的慢性炎症和纤维化。若未经适当的临床管理，进行性的胆管和肝脏损伤会导致肝硬化，并最终导致肝衰竭。目前治疗这种胆管病的药物作用有限，这促使研究人员评估其他治疗选择。一些草药及其植物化学成分在不同的肝病实验模型中，偶尔也在原发性硬化性胆管炎患者的临床试验中显示出抗纤维化特性；然而，其作用机制尚未完全明确。本综述简要考察了聚焦于[具体草药或成分]、[具体草药或成分]、[具体草药或成分]和槲皮素潜在抗纤维化特性的相关研究。对每种天然产物分别进行综述，并讨论其可能的作用机制。
