Doretto Larissa, Mari Flora Chaves, Chaves Ana Cristina
First Episode Psychosis Program, Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil.
Santa Casa Medical School of Sao Paulo, Sao Paulo, Brazil.
Front Psychiatry. 2020 Jun 10;11:543. doi: 10.3389/fpsyt.2020.00543. eCollection 2020.
Polycystic ovary syndrome (PCOS), a disease that usually emerges during adolescence, is characterized by hormonal imbalance and ovarian dysfunction. The prevalence can vary between 5.6 to 21.3% in women and 6% in adolescent girls. This discrepancy is related to the population studied and the diagnostic criteria used. The underlying pathophysiology of PCOS is not fully understood, but it can lead to a number of co-morbidities, including hypertension, diabetes, dyslipidemia, and also, mental health disorders. Clinical and preclinical data indicate neuroendocrine involvement with dysfunction in gamma-Aminobutyric acid (GABA) signaling and neuronal androgen receptors that might reduce hypothalamic sensitivity and lead to an impairment of estradiol and progesterone feedback. Based on these assumptions, the aims of this paper are to review the association of PCOS and psychotic disorders in order to address the burden of women comorbid for both conditions.
多囊卵巢综合征（PCOS）通常在青春期出现，其特征是激素失衡和卵巢功能障碍。女性患病率在5.6%至21.3%之间，青春期女孩患病率为6%。这种差异与所研究的人群和使用的诊断标准有关。PCOS的潜在病理生理学尚未完全了解，但它可导致多种合并症，包括高血压、糖尿病、血脂异常，以及心理健康障碍。临床和临床前数据表明，神经内分泌参与了γ-氨基丁酸（GABA）信号传导功能障碍和神经元雄激素受体功能障碍，这可能会降低下丘脑敏感性，导致雌二醇和孕酮反馈受损。基于这些假设，本文旨在综述PCOS与精神障碍的关联，以应对同时患有这两种疾病的女性的负担。
