Kryzhanovskiĭ G N, Atadzhanov M A, Zagorevskiĭ V A, Sharkova L M, Voronina T A
Biull Eksp Biol Med. 1988 Apr;105(4):397-401.
Systemic administration of high doses of MPTP caused transient bradykinesia, "freezing" episodes, head tremors, hunching of the back and peripheral autonomic effects. Neurological syndrome was clearly dose-dependent. It has been established that Parkinson's syndrome is caused by high-amplitude paroxysmal discharges in the nucleus caudatis. It is concluded that the nucleus caudatis plays the role of a pathological determinant structure in the development of Parkinson's syndrome induced by MPTP.
高剂量MPTP的全身给药导致短暂性运动迟缓、“冻结”发作、头部震颤、背部弓起及外周自主神经效应。神经综合征明显呈剂量依赖性。已经确定帕金森综合征是由尾状核中的高振幅阵发性放电引起的。结论是，尾状核在MPTP诱导的帕金森综合征发展中起病理决定结构的作用。
