Department of National Defense Technology, Woosuk University, Daehak-ro 66, Jincheon-eup Jincheon-gun, Chungcheongbuk-do 27841, Republic of Korea.
Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea.
J Immunol Res. 2020 Jun 8;2020:4768390. doi: 10.1155/2020/4768390. eCollection 2020.
Among potent dietary supplements, , commonly called bitter melon, has various biological effects, such as antioxidant and anti-inflammatory effects, and improves energy metabolism and fatigue recovery. However, it is unknown whether extract (MCE) induces antifatigue effects during exercise training in high-temperature environments. This study aimed at investigating the efficacy of MCE by examining 10 male tennis players consuming 100 mL MCE/dose (6 times a day over 4 weeks) during the summer training season. Peripheral (ammonia and uric acid) and central (serotonin, dopamine, and prolactin) fatigue parameters were measured before and after MCE consumption; before, during, and after exercise; and the next morning. After consuming MCE supplements, ammonia levels were higher during and after exercise and recovered the next morning, whereas uric acid levels did not change at any time point. Serotonin levels were lower during exercise. Dopamine levels were higher, especially during exercise. Prolactin levels were lower at all time points, especially during and after exercise. Although high-intensity training in a hot environment causes accumulation of fatigue-related metabolites, our results indicate that 4 weeks of MCE intake positively influenced fatigue parameters, suggesting that MCE can efficiently combat fatigue.
在有效的膳食补充剂中，苦瓜素有各种生物学作用，如抗氧化和抗炎作用，能改善能量代谢和疲劳恢复。然而，在高温环境下的运动训练中，苦瓜提取物（MCE）是否能产生抗疲劳作用尚不清楚。本研究旨在通过观察 10 名男性网球运动员在夏季训练期间每天服用 100 毫升 MCE（每天 6 次，持续 4 周）来评估 MCE 的功效。在服用 MCE 前后、运动前、运动中和运动后以及第二天早上测量外周（氨和尿酸）和中枢（血清素、多巴胺和催乳素）疲劳参数。在服用 MCE 补充剂后，运动中和运动后氨的水平升高，而第二天早上恢复正常，而尿酸水平在任何时间点都没有变化。运动时血清素水平较低。多巴胺水平较高，尤其是在运动时。催乳素水平在所有时间点都较低，尤其是在运动中和运动后。尽管在炎热的环境中进行高强度训练会导致与疲劳相关的代谢物积累，但我们的结果表明，4 周的 MCE 摄入对疲劳参数有积极影响，表明 MCE 能有效地对抗疲劳。
