喀麦隆的第二项基于人群的队列研究证实了盘尾丝虫病与癫痫之间的时间关系。
A Second Population-Based Cohort Study in Cameroon Confirms the Temporal Relationship Between Onchocerciasis and Epilepsy.
作者信息
Chesnais Cédric B, Bizet Charlotte, Campillo Jérémy T, Njamnshi Wepnyu Y, Bopda Jean, Nwane Philippe, Pion Sébastien D, Njamnshi Alfred K, Boussinesq Michel
机构信息
UMI 233, Institut de Recherche pour le Développement (IRD), Université Montpellier, INSERM Unité 1175, Montpellier, France.
Centre for Research on Filariasis and other Tropical Diseases (CRFilMT), Yaoundé, Cameroon.
出版信息
Open Forum Infect Dis. 2020 Jun 2;7(6):ofaa206. doi: 10.1093/ofid/ofaa206. eCollection 2020 Jun.
Abstract
To confirm our earlier evidence of a temporal and dose-response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon. Individuals whose microfilarial density (-MFD) was measured in 1992-1994 when they were children were revisited in 2019 to determine if they acquired epilepsy. With reference to individuals with no microfilariae in 1992-1994, the relative risks of acquiring epilepsy were 0.96, 2.76, 3.67, and 11.87 in subjects with initial -MFD of 1-7, 8-70, 71-200, and > 200 microfilariae per skin snip, respectively. This study further demonstrates reproducibility using the Bradford Hill's criteria for causality.
摘要
为了证实我们之前关于盘尾丝虫病与癫痫之间存在时间和剂量反应关系的证据，我们在喀麦隆的另一个地区开展了另一项队列研究。对那些在1992年至1994年儿童时期测量过微丝蚴密度（-MFD）的个体，于2019年再次进行回访，以确定他们是否患上了癫痫。与1992年至1994年无微丝蚴的个体相比，初始-MFD分别为每皮肤切片1-7、8-70、71-200和>200条微丝蚴的受试者患癫痫的相对风险分别为0.96、2.76、3.67和11.87。本研究进一步证明了使用布拉德福德·希尔因果关系标准的可重复性。
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