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Impact of 19 years of mass drug administration with ivermectin on epilepsy burden in a hyperendemic onchocerciasis area in Cameroon.19 年伊维菌素群体药物治疗对喀麦隆高度流行区癫痫负担的影响。
Parasit Vectors. 2019 Mar 19;12(1):114. doi: 10.1186/s13071-019-3345-7.
2
Clinical presentations of onchocerciasis-associated epilepsy (OAE) in Cameroon.喀麦隆盘尾丝虫病相关性癫痫（OAE）的临床表现。
Epilepsy Behav. 2019 Jan;90:70-78. doi: 10.1016/j.yebeh.2018.11.008. Epub 2018 Dec 1.
3
The temporal relationship between onchocerciasis and epilepsy: a population-based cohort study.盘尾丝虫病和癫痫之间的时间关系：基于人群的队列研究。
Lancet Infect Dis. 2018 Nov;18(11):1278-1286. doi: 10.1016/S1473-3099(18)30425-0. Epub 2018 Sep 26.
4
Burden of onchocerciasis-associated epilepsy: first estimates and research priorities.盘尾丝虫病相关癫痫负担：首次估计和研究重点。
Infect Dis Poverty. 2018 Sep 19;7(1):101. doi: 10.1186/s40249-018-0481-9.
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Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa.撒哈拉以南非洲地区癫痫的流行病学、病因及治疗
Lancet Neurol. 2014 Oct;13(10):1029-44. doi: 10.1016/S1474-4422(14)70114-0.
6
Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan Africa.在撒哈拉以南非洲地区，接触多种寄生虫与活动性惊厥性癫痫的患病率相关。
PLoS Negl Trop Dis. 2014 May 29;8(5):e2908. doi: 10.1371/journal.pntd.0002908. eCollection 2014.
7
Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis.关于盘尾丝虫病与癫痫关系的病例对照研究：系统评价和荟萃分析。
PLoS Negl Trop Dis. 2013;7(3):e2147. doi: 10.1371/journal.pntd.0002147. Epub 2013 Mar 28.
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Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies.撒哈拉以南非洲活动性癫痫的患病率及相关危险因素：横断面和病例对照研究。
Lancet Neurol. 2013 Mar;12(3):253-63. doi: 10.1016/S1474-4422(13)70003-6. Epub 2013 Jan 31.
9
Epilepsy in poor regions of the world.世界贫困地区的癫痫
Lancet. 2012 Sep 29;380(9848):1193-201. doi: 10.1016/S0140-6736(12)61381-6.
10
Estimation of the burden of active and life-time epilepsy: a meta-analytic approach.估算活动性癫痫和终身癫痫的负担：一项荟萃分析方法。
Epilepsia. 2010 May;51(5):883-90. doi: 10.1111/j.1528-1167.2009.02481.x. Epub 2010 Jan 7.

喀麦隆的第二项基于人群的队列研究证实了盘尾丝虫病与癫痫之间的时间关系。

A Second Population-Based Cohort Study in Cameroon Confirms the Temporal Relationship Between Onchocerciasis and Epilepsy.

作者信息

Chesnais Cédric B, Bizet Charlotte, Campillo Jérémy T, Njamnshi Wepnyu Y, Bopda Jean, Nwane Philippe, Pion Sébastien D, Njamnshi Alfred K, Boussinesq Michel

机构信息

UMI 233, Institut de Recherche pour le Développement (IRD), Université Montpellier, INSERM Unité 1175, Montpellier, France.

Centre for Research on Filariasis and other Tropical Diseases (CRFilMT), Yaoundé, Cameroon.

出版信息

Open Forum Infect Dis. 2020 Jun 2;7(6):ofaa206. doi: 10.1093/ofid/ofaa206. eCollection 2020 Jun.

DOI:10.1093/ofid/ofaa206
PMID:32587878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7304933/
Abstract

To confirm our earlier evidence of a temporal and dose-response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon. Individuals whose microfilarial density (-MFD) was measured in 1992-1994 when they were children were revisited in 2019 to determine if they acquired epilepsy. With reference to individuals with no microfilariae in 1992-1994, the relative risks of acquiring epilepsy were 0.96, 2.76, 3.67, and 11.87 in subjects with initial -MFD of 1-7, 8-70, 71-200, and > 200 microfilariae per skin snip, respectively. This study further demonstrates reproducibility using the Bradford Hill's criteria for causality.

摘要

为了证实我们之前关于盘尾丝虫病与癫痫之间存在时间和剂量反应关系的证据，我们在喀麦隆的另一个地区开展了另一项队列研究。对那些在1992年至1994年儿童时期测量过微丝蚴密度（-MFD）的个体，于2019年再次进行回访，以确定他们是否患上了癫痫。与1992年至1994年无微丝蚴的个体相比，初始-MFD分别为每皮肤切片1-7、8-70、71-200和>200条微丝蚴的受试者患癫痫的相对风险分别为0.96、2.76、3.67和11.87。本研究进一步证明了使用布拉德福德·希尔因果关系标准的可重复性。