Gaitán Julian M, Boots Elizabeth A, Dougherty Ryan J, Ma Yue, Edwards Dorothy F, Mitchell Carol C, Christian Bradley T, Cook Dane B, Okonkwo Ozioma C
Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Department of Kinesiology, University of Wisconsin School of Education, Madison, WI, USA.
J Alzheimers Dis Rep. 2020 May 2;4(1):107-121. doi: 10.3233/ADR-200180.
A growing body of evidence supports that aerobic exercise can decrease the risk of future cognitive impairment and Alzheimer's disease (AD). There is a pressing need to rigorously determine whether cognitively normal yet at-risk individuals stand to benefit from the protective effects of exercise. The present study will test the feasibility of an aerobic exercise intervention in such a population and inform the design of a larger-scale randomized, controlled trial examining the effect of aerobic exercise on biomarkers of AD in late-middle-aged, at-risk individuals. This was a single-site, 1 : 1 block-randomized, parallel, two-arm trial. Cognitively normal participants aged 45-80 with documentation of familial and genetic AD risk factors were randomly assigned to one of two interventions. The Usual Physical Activity group was provided educational materials about exercise. The Enhanced Physical Activity intervention delivered 26 weeks of individualized and supervised aerobic exercise. Exercise duration and intensity were incrementally increased to 150 min/week and 70-80% of heart rate reserve, respectively. Retention and adherence were measured to assess study feasibility. In addition, pre- and post- intervention differences between the two arms were evaluated for cardiorespiratory fitness, physical activity, brain glucose metabolism, cerebral structure, vascular health, memory, executive function, and mood. Data from randomized controlled trials of exercise training are needed to identify the proper exercise prescription for reducing accumulation of AD biomarkers in cognitively normal individuals. The current trial will contribute to filling that gap while informing the design of large-scale trials.
越来越多的证据支持有氧运动可以降低未来认知障碍和阿尔茨海默病（AD）的风险。迫切需要严格确定认知正常但处于风险中的个体是否能从运动的保护作用中获益。本研究将测试有氧运动干预在此类人群中的可行性，并为一项更大规模的随机对照试验的设计提供信息，该试验将研究有氧运动对中老年、有风险个体的AD生物标志物的影响。这是一项单中心、1:1区组随机、平行、双臂试验。年龄在45 - 80岁、有家族性和遗传性AD风险因素记录的认知正常参与者被随机分配到两种干预措施之一。常规身体活动组被提供有关运动的教育材料。强化身体活动干预提供26周的个性化和有监督的有氧运动。运动持续时间和强度分别逐步增加到每周150分钟和心率储备的70 - 80%。测量保留率和依从性以评估研究的可行性。此外，评估两组干预前后在心肺适能、身体活动、脑葡萄糖代谢、脑结构、血管健康、记忆、执行功能和情绪方面的差异。需要来自运动训练随机对照试验的数据来确定适当的运动处方，以减少认知正常个体中AD生物标志物的积累。当前的试验将有助于填补这一空白，同时为大规模试验的设计提供信息。
