Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands.
Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
J Nutr. 2020 Aug 1;150(8):2112-2119. doi: 10.1093/jn/nxaa149.
Hong Kong faces several public health problems including malnutrition and osteoporosis. Considering the typical Chinese diet and overall low physical activity levels of Chinese adults, timely interventions to improve nutritional status and bone health are needed.
We examined the effects of a nutrition plus exercise intervention on serum vitamin B-12 and 25-hydroxyvitamin D [25(OH)D], bone turnover markers, and parathyroid hormone (PTH) concentrations in apparently healthy Chinese middle-aged and older adults.
In this 24-wk randomized controlled trial, 180 Chinese adults (85 women, mean ± SD age: 61 ± 6 y) were randomly assigned to receive a fortified milk supplement (2 × 30 g/d) and an exercise program (2 × 1 h/wk including resistance, balance, and aerobic training) or no intervention. The primary outcome was physical performance. In this article we analyzed the secondary outcomes serum vitamin B-12 and 25(OH)D concentrations, assessed at baseline, 12 wk, and 24 wk. Also, bone turnover markers and PTH concentrations were studied. Linear mixed models evaluated group differences over time.
A significant time × group interaction (P < 0.001) was found for serum vitamin B-12 and 25(OH)D concentrations and the bone turnover markers, but not for serum PTH concentrations (P = 0.09). The intervention increased mean ± SD vitamin B-12 concentrations from baseline (345 ± 119 pmol/L) to 24 wk (484 ± 136 pmol/L), whereas concentrations remained stable within the control. For 25(OH)D concentrations, the intervention group had a greater increase from baseline (54.7 ± 14.2 nmol/L) to 24 wk (80.1 ± 19.2 nmol/L) than the control (60.6 ± 15.2 compared with 65.6 ± 14.6 nmol/L). The ratio of the net effect of bone formation and resorption was greater in the intervention group, suggesting less bone remodeling, irrespective of sex.
A fortified milk supplement and exercise intervention successfully improved vitamin B-12 and 25(OH)D concentrations as well as the balance of bone turnover markers of Chinese middle-aged and older adults.This trial was registered at trialregister.nl as NTR6214.
香港面临着多种公共卫生问题，包括营养不良和骨质疏松症。考虑到典型的中式饮食和中国成年人整体较低的身体活动水平，需要及时采取干预措施来改善营养状况和骨骼健康。
我们研究了营养加运动干预对貌似健康的中国中老年人血清维生素 B-12 和 25-羟维生素 D [25(OH)D]、骨转换标志物和甲状旁腺激素 (PTH) 浓度的影响。
在这项为期 24 周的随机对照试验中，180 名中国成年人（85 名女性，平均年龄 ± 标准差：61 ± 6 岁）被随机分配接受强化牛奶补充剂（2×30 g/d）和运动方案（2×1 小时/周，包括阻力、平衡和有氧运动训练）或不干预。主要结局是身体表现。在本文中，我们分析了次要结局血清维生素 B-12 和 25(OH)D 浓度，在基线、12 周和 24 周时进行评估。还研究了骨转换标志物和 PTH 浓度。线性混合模型评估了组间随时间的差异。
发现血清维生素 B-12 和 25(OH)D 浓度以及骨转换标志物的时间×组交互作用有显著差异（P<0.001），但血清 PTH 浓度无显著差异（P=0.09）。干预使平均 ± 标准差维生素 B-12 浓度从基线（345±119 pmol/L）升高到 24 周（484±136 pmol/L），而对照组的浓度保持稳定。对于 25(OH)D 浓度，干预组从基线（54.7±14.2 nmol/L）升高到 24 周（80.1±19.2 nmol/L）的幅度大于对照组（60.6±15.2 与 65.6±14.6 nmol/L）。骨形成和骨吸收的净效应比值在干预组更大，表明骨重塑减少，与性别无关。
强化牛奶补充剂和运动干预成功改善了中国中老年人的维生素 B-12 和 25(OH)D 浓度以及骨转换标志物的平衡。这项试验在 trialregister.nl 上注册为 NTR6214。
