Department of Material Dependence, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Anhui Clinical Research Centre for Mental Disorders, Anhui Mental Health Centre, Hefei, China.
J Int Med Res. 2024 Oct;52(10):3000605241291759. doi: 10.1177/03000605241291759.
To investigate the prevalence of low bone mineral density (BMD) along with its possible risk factors in male Han Chinese patients with alcohol dependence (AD).
This retrospective, cross-sectional study included male patients with AD, classified into normal and low BMD groups according to bone densitometry T scores. Demographic and alcohol-related data, and routine laboratory parameters were compared between the two groups. Binary logistic regression analysis was employed to evaluate risk factors associated with low BMD, and correlations between the T-score and demographic, alcohol-related, and routine laboratory data were evaluated.
Among a total of 107 patients with AD included in the study, the prevalence of low BMD was 70.09% (75/107). Patients with low BMD were older, consumed more alcohol daily, and had higher lactate dehydrogenase (LDH) and lower Ca levels than patients with normal BMD. Regression analysis revealed that increased daily alcohol intake, low serum Ca levels, high serum LDH levels, and comorbid hypertension was related to low BMD in patients with AD. Further correlation analysis revealed a positive association between T-score and serum Ca levels.
Increased daily alcohol intake, low serum Ca levels, high serum LDH levels, and comorbid hypertension may be risk factors for low BMD.
探讨男性汉族酒精依赖（AD）患者低骨密度（BMD）的患病率及其可能的危险因素。
本回顾性横断面研究纳入了男性 AD 患者，根据骨密度 T 评分将其分为正常 BMD 组和低 BMD 组。比较两组患者的人口统计学和酒精相关数据以及常规实验室参数。采用二项逻辑回归分析评估与低 BMD 相关的危险因素，并评估 T 评分与人口统计学、酒精相关和常规实验室数据之间的相关性。
在纳入研究的 107 例 AD 患者中，低 BMD 的患病率为 70.09%（75/107）。与正常 BMD 患者相比，低 BMD 患者年龄更大，每日饮酒量更多，且乳酸脱氢酶（LDH）更高，血清 Ca 水平更低。回归分析显示，每日饮酒量增加、血清 Ca 水平降低、血清 LDH 水平升高以及合并高血压与 AD 患者的低 BMD 相关。进一步的相关性分析显示，T 评分与血清 Ca 水平呈正相关。
每日饮酒量增加、血清 Ca 水平降低、血清 LDH 水平升高以及合并高血压可能是低 BMD 的危险因素。
