C-F 和 C-N 键的交叉亲电偶联断裂在 -二氟烯烃合成中的应用。
Merger of C-F and C-N Bond Cleavage in Cross-Electrophile Coupling for the Synthesis of -Difluoroalkenes.
机构信息
Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
Center for Excellence in Molecular Synthesis of CAS, Hefei, Anhui 230026, P. R. China.
出版信息
Org Lett. 2020 Jul 17;22(14):5347-5352. doi: 10.1021/acs.orglett.0c01592. Epub 2020 Jun 26.
Herein we successfully applied Katritzky salts as the alkyl electrophile in the reductive allylic defluorinative cross-coupling reaction with α-trifluoromethyl alkenes. The merger of C-F and C-N bond cleavage via the synergistic effect of nickel and zinc allows the efficient synthesis of diverse -difluoroalkenes with a good tolerance for various functional groups.
在此，我们成功地将 Katritzky 盐作为烷基亲电试剂应用于α-三氟甲基烯烃的还原烯丙基脱氟交叉偶联反应中。镍和锌的协同作用实现了 C-F 和 C-N 键的断裂融合，从而使各种具有良好官能团容忍度的 -二氟烯烃得以高效合成。
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