Liu Yeqing, Tao Xiangzhang, Mao Yu, Yuan Xin, Qiu Jiangkai, Kong Linyu, Ni Shengyang, Guo Kai, Wang Yi, Pan Yi
Jiangsu Key Laboratory of Advanced Organic Materials, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China.
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Road South, Nanjing, 211816, China.
Nat Commun. 2021 Nov 19;12(1):6745. doi: 10.1038/s41467-021-27060-7.
Electrosynthesis has received great attention among researchers in both academia and industry as an ideal technique to promote single electron reduction without the use of expensive catalysts. In this work, we report the electrochemical reduction of Katritzky salts to alkyl radicals by sacrificing the easily accessible metal anode. This catalyst and electrolyte free platform has broad applicability to single electron transfer chemistry, including fluoroalkenylation, alkynylation and thiolation. The deaminative functionalization is facilitated by the rapid molecular diffusion across microfluidic channels, demonstrating the practicality that outpaces the conventional electrochemistry setups.
作为一种无需使用昂贵催化剂即可促进单电子还原的理想技术，电合成在学术界和工业界的研究人员中都受到了极大关注。在这项工作中，我们报告了通过牺牲易于获取的金属阳极将卡特里茨基盐电化学还原为烷基自由基。这个无催化剂和电解质的平台在单电子转移化学中具有广泛的适用性，包括氟代烯基化、炔基化和硫醇化。脱氨基官能化通过分子在微流控通道中的快速扩散得以促进，这证明了其超越传统电化学装置的实用性。
