Center for Alzheimer's Disease, Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil, Universidade Federal do Rio de Janeiro, Avenida Venceslau Brás, 71 (Fundos), Botafogo, Rio de Janeiro - RJ, 21941-901, Brazil.
Curr Alzheimer Res. 2020;17(5):487-497. doi: 10.2174/1567205017666200626205154.
Social Cognition (SC) is a complex construct that reflects a wide variety of implicit and explicit cognitive processes. Many neurocognitive domains are associated with SC and the Executive Function (EF) is the most representative one. We conducted a systematic review aiming at clarifying whether SC impairments are associated with dysfunction on EF in people with Alzheimer Disease (AD).
The search, based on the Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA), was undertaken between January 2007 and December 2019 using Pubmed, SciELO, BIREME and Thomson Reuters Web of Science electronic databases. The keywords were SC, AD, EF, Neuropsychological functioning and Executive Disorder.
One hundred thirty-six articles were identified and fifteen were included. These studies are not in agreement about the extent of SC deficits in AD, mainly in the mild stage of the disease. EF deficits, specifically inhibition and the ability to manipulate verbal information, are associated with the impairment in SC in AD. SC decreases with the disease progression, a relationship explained by global cognition impairment and SC specific symptoms.
SC impairment is associated with disease progression, mainly because of the decline in EF. Studies on SC components are unequal, contributing to a frequent generalization of Theory of Mind results, and often hampering the investigation of other components, mainly empathy. More precise knowledge about SC functioning in AD may contribute to a better understanding of the behavioral changes and interpersonal interactions.
社会认知（SC）是一个复杂的结构，反映了广泛的内隐和外显认知过程。许多神经认知领域与 SC 相关，而执行功能（EF）是最具代表性的。我们进行了一项系统评价，旨在阐明在阿尔茨海默病（AD）患者中，SC 损伤是否与 EF 功能障碍有关。
基于系统评价和荟萃分析的首选报告项目（PRISMA）的检索，于 2007 年 1 月至 2019 年 12 月在 Pubmed、SciELO、BIREME 和 Thomson Reuters Web of Science 电子数据库中进行。关键词为 SC、AD、EF、神经心理功能和执行障碍。
共确定了 136 篇文章，其中 15 篇被纳入。这些研究对 AD 中 SC 缺陷的程度并不一致，主要是在疾病的轻度阶段。EF 缺陷，特别是抑制和操纵言语信息的能力，与 AD 中的 SC 损伤有关。SC 随疾病的进展而下降，这种关系可以用整体认知损伤和 SC 特定症状来解释。
SC 损伤与疾病的进展有关，主要是因为 EF 的下降。关于 SC 成分的研究不平等，导致心理理论结果经常被泛化，并且经常阻碍对其他成分的研究，主要是同理心。对 AD 中 SC 功能的更精确了解可能有助于更好地理解行为变化和人际互动。
