Etiopatogènia i Tractament dels Trastorns Mentals Greus (MERITT), Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain; Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain; Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Etiopatogènia i Tractament dels Trastorns Mentals Greus (MERITT), Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain; Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain.
Span J Psychiatry Ment Health. 2024 Jul-Sep;17(3):160-167. doi: 10.1016/j.sjpmh.2024.01.002. Epub 2024 Jan 12.
Social cognition (SC) and executive function (EF) have been described as important variables for social functioning and recovery of patients with psychosis. However, the relationship between SC and EF in first-episode psychosis (FEP) deserves further investigation, especially focusing on gender differences.
To investigate the relationship between EF and different domains of SC in FEP patients and to explore gender differences in the relationship between these domains.
A cross-sectional study of 191 patients with new-onset psychosis recruited from two multicenter clinical trials. A comprehensive cognitive battery was used to assess SC (Hinting Task, Face Test and IPSAQ) and EF (TMT, WSCT, Stroop Test and digit span - WAIS-III). Pearson correlations and linear regression models were performed.
A correlation between Theory of Mind (ToM), Emotional Recognition (ER) and EF was found using the complete sample. Separating the sample by gender showed different association profiles between these variables in women and men.
A relationship between different domains of SC and EF is found. Moreover, women and men presented distinct association profiles between EF and SC. These results should be considered in order to improve the treatment of FEP patients and designing personalized interventions by gender.
社会认知（SC）和执行功能（EF）已被描述为精神疾病患者社交功能和康复的重要变量。然而，首次发作精神病（FEP）患者的 SC 和 EF 之间的关系值得进一步研究，特别是关注性别差异。
研究 FEP 患者 EF 和 SC 不同领域之间的关系，并探讨这些领域之间关系的性别差异。
对来自两项多中心临床试验的 191 名新发精神病患者进行横断面研究。使用综合认知电池评估 SC（暗示任务、面部测试和 IPSAQ）和 EF（TMT、WSCT、Stroop 测试和数字跨度-WAIS-III）。进行 Pearson 相关性和线性回归模型。
使用完整样本发现了心理理论（ToM）、情绪识别（ER）和 EF 之间的相关性。按性别对样本进行划分后，女性和男性之间这些变量之间的关联模式不同。
发现了 SC 和 EF 的不同领域之间存在关系。此外，EF 和 SC 之间在女性和男性中呈现出不同的关联模式。应该考虑这些结果，以便通过性别改善 FEP 患者的治疗和设计个性化干预措施。
