TiFoSi：上皮细胞的机械生物学模拟的高效工具。
TiFoSi: an efficient tool for mechanobiology simulations of epithelia.
机构信息
MRC Human Genetics Unit at the MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Chemical and Biomolecular Engineering Department.
出版信息
Bioinformatics. 2020 Aug 15;36(16):4525-4526. doi: 10.1093/bioinformatics/btaa592.
MOTIVATION
Emerging phenomena in developmental biology and tissue engineering are the result of feedbacks between gene expression and cell biomechanics. In that context, in silico experiments are a powerful tool to understand fundamental mechanisms and to formulate and test hypotheses.
RESULTS
Here, we present TiFoSi, a computational tool to simulate the cellular dynamics of planar epithelia. TiFoSi allows to model feedbacks between cellular mechanics and gene expression (either in a deterministic or a stochastic way), the interaction between different cell populations, the custom design of the cell cycle and cleavage properties, the protein number partitioning upon cell division, and the modeling of cell communication (juxtacrine and paracrine signaling).
AVAILABILITY AND IMPLEMENTATION
http://tifosi.thesimbiosys.com.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
动机
发育生物学和组织工程学中的新兴现象是基因表达和细胞生物力学之间反馈的结果。在这种情况下，计算机模拟实验是理解基本机制以及提出和检验假设的有力工具。
结果
在这里，我们提出了 TiFoSi，这是一种用于模拟平面上皮细胞动力学的计算工具。TiFoSi 允许模拟细胞力学和基因表达之间的反馈（无论是确定性的还是随机性的），不同细胞群体之间的相互作用，细胞周期和分裂特性的自定义设计，细胞分裂时的蛋白质数量分配，以及细胞通讯（旁分泌和内分泌信号）的建模。
可用性和实现
http://tifosi.thesimbiosys.com。
补充信息
补充数据可在 Bioinformatics 在线获得。
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