Zhang Ting, He Liang, Wang Zhihong, Dong Wenwu, Sun Wei, Zhang Ping, Zhang Hao
Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
J Int Med Res. 2020 Jun;48(6):300060520920433. doi: 10.1177/0300060520920433.
Thyroid follicular dendritic cell sarcoma (FDCS) is an extremely rare malignancy that originates from follicular dendritic cells of the germinal centers and is characterized by the neoplastic proliferation of spindled to ovoid cells. As there have been only five cases reported in the literature until now, the diagnostic and therapeutic information available to clinicians regarding thyroid FDCS is fairly limited. To our knowledge, this is the first case report of thyroid FDCS without a history of Hashimoto's thyroiditis. A 48-year-old woman was found to have a slow-growing mass in the left thyroid. After total thyroidectomy and left modified radical neck dissection, the specimen demonstrated morphologic and immunohistochemical features of FDCS. The patient had a favorable prognosis with no evidence of disease 11 months after tumor excision.
甲状腺滤泡树突状细胞肉瘤（FDCS）是一种极其罕见的恶性肿瘤，起源于生发中心的滤泡树突状细胞，其特征是梭形至卵圆形细胞的肿瘤性增殖。由于迄今为止文献中仅报道了5例，临床医生可获得的关于甲状腺FDCS的诊断和治疗信息相当有限。据我们所知，这是首例无桥本甲状腺炎病史的甲状腺FDCS病例报告。一名48岁女性被发现左甲状腺有一生长缓慢的肿块。在进行全甲状腺切除和左侧改良根治性颈清扫术后，标本显示出FDCS的形态学和免疫组化特征。肿瘤切除11个月后，患者预后良好，无疾病证据。
