Wang Yongchun, Zhou Min, Wang Feifei, Hu Zhiyan, Ruan Yan
Department of Otolaryngology, The Institute of The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Guangzhou University of Chinese Medicine, The First Clinical Medical College, Guangzhou, China.
Front Oncol. 2025 Jul 3;15:1512156. doi: 10.3389/fonc.2025.1512156. eCollection 2025.
As a relatively rare malignant entity, follicular dendritic cell sarcoma (FDCS) of the mediastinum currently suffers from insufficient clinical characterization, warranting more comprehensive studies to optimize therapeutic strategies. The initial symptoms of FDCS are often related to the respiratory system. It is particularly rare for the disease to present initially as recurrent ulcers in the oropharynx, which eventually led to a diagnosis of paraneoplastic pemphigus. Here, we report a case of a young female patient diagnosed with mediastinal FDCS associated with paraneoplastic pemphigus. The patient presented with recurrent pharyngeal ulcers and was diagnosed with mediastinal FDCS associated with paraneoplastic pemphigus 10 months later through imaging and pathological examinations.
作为一种相对罕见的恶性肿瘤，纵隔滤泡性树突状细胞肉瘤（FDCS）目前临床特征描述不足，需要更全面的研究来优化治疗策略。FDCS的初始症状通常与呼吸系统有关。该病最初表现为口咽反复溃疡并最终导致副肿瘤性天疱疮的诊断极为罕见。在此，我们报告一例年轻女性患者，诊断为与副肿瘤性天疱疮相关的纵隔FDCS。该患者出现咽部反复溃疡，10个月后通过影像学和病理检查诊断为与副肿瘤性天疱疮相关的纵隔FDCS。
