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PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy.
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Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins.
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Autophagy and polyglutamine diseases.
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Promoting proteostasis by cAMP/PKA and cGMP/PKG.
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Sustained but Decoyed Activation of the JAK1-STAT Pathway by Aberrant Protein Aggregation Exacerbates Proteotoxicity.
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Chemical inhibition of the integrated stress response impairs the ubiquitin-proteasome system.
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Editorial: Proteostasis in cardiac health and disease.
Front Mol Biosci. 2024 May 31;11:1433721. doi: 10.3389/fmolb.2024.1433721. eCollection 2024.
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Genetic blockade of the activation of 26S proteasomes by PKA is well tolerated by mice at baseline.
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S14-Phosphorylated RPN6 Mediates Proteasome Activation by PKA and Alleviates Proteinopathy.
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The double-hit protocol induces HFpEF and impairs myocardial ubiquitin-proteasome system performance in FVB/N mice.
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10
Role of Proteostasis Regulation in the Turnover of Stress Granules.
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本文引用的文献

1
PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy.
Sci Adv. 2019 May 22;5(5):eaaw5870. doi: 10.1126/sciadv.aaw5870. eCollection 2019 May.
2
Proteostasis and Beyond: ATF6 in Ischemic Disease.
Trends Mol Med. 2019 Jun;25(6):538-550. doi: 10.1016/j.molmed.2019.03.005. Epub 2019 May 8.
3
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression.
Cell. 2019 Apr 18;177(3):737-750.e15. doi: 10.1016/j.cell.2019.03.035.
4
26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation.
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4228-4237. doi: 10.1073/pnas.1809254116. Epub 2019 Feb 19.
5
Cardiomyopathy with lethal arrhythmias associated with inactivation of KLHL24.
Hum Mol Genet. 2019 Jun 1;28(11):1919-1929. doi: 10.1093/hmg/ddz032.
6
PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress.
Nature. 2019 Feb;566(7743):264-269. doi: 10.1038/s41586-019-0895-y. Epub 2019 Jan 30.
7
Getting to the Heart of Alzheimer Disease.
Circ Res. 2019 Jan 4;124(1):142-149. doi: 10.1161/CIRCRESAHA.118.313563.
9
Exploring the Regulation of Proteasome Function by Subunit Phosphorylation.
Methods Mol Biol. 2018;1844:309-319. doi: 10.1007/978-1-4939-8706-1_20.
10
Regulation of proteasome assembly and activity in health and disease.
Nat Rev Mol Cell Biol. 2018 Nov;19(11):697-712. doi: 10.1038/s41580-018-0040-z.

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